Cross dehydrogenative coupling (CDC) reactions have become a convenient synthetic
strategy for the synthesis of various (het) aromatic scaffolds. In recent times ball milling has …

We have shown that nanoparticles (NPs) conjugated to trans-activating transcriptor (TAT)
peptide bypass the efflux action of P-glycoprotein and increase the transport of the …

Retrometabolic drug design (RMDD) approaches are systematic methodologies aimed to
design safe compounds with an improved therapeutic index. RMDDs thoroughly integrate …

Innovative approach to drug design that's more likely to result in an approvable drug product
Retrometabolic drug design incorporates two distinct drug design approaches to obtain soft …

An efficient asymmetric tandem reaction of o-alkynylbenzaldehydes, amines, and diazo
compounds catalyzed by chiral silver imidodiphosphate has been established. Chiral 1, 2 …

An efficient asymmetric acyl-Mannich reaction of isoquinolines with α-(diazomethyl)
phosphonate and diazoacetate has been developed using chiral spiro phosphoric acids as …

A one-pot and efficient approach to the synthesis of dialkyl 2-[1-[(alkoxycarbonyl) anilino]-2
(1H)-(isoquinolin-2-yl)(or-quinolin-1-yl or-pyridin-1-yl)]-2-butenedioates is described. This …

An unexpected, novel, three-component reaction between isoquinoline, an isocyanide and
strong CH-acids in water - ScienceDirect Skip to main contentSkip to article Elsevier logo …

In this research the preparation of pyrimidoisoquinoline derivatives were performed by using
four-component reactions of 4-aminocumarin, isocyanides, phthalaldehyde and ammonium …

An isomerization‐ring‐closing metathesis (RCM) approach was used for the synthesis of
substituted 2, 3‐dihydro‐1H‐2‐benzazepines and 1, 2‐dihydroisoquinolines. The 2, 3 …