Antibacterial resistance is one of the greatest threats to human health. The development of
new therapeutics against bacterial pathogens has slowed drastically since the approvals of …

In this Review, we explore natural product antibiotics that do more than simply inhibit an
active site of an essential enzyme. We review these compounds to provide inspiration for the …

Advances in areas that include genomics, systems biology, protein structure determination
and artificial intelligence provide new opportunities for target-based antibacterial drug …

Darobactin is a heptapeptide antibiotic featuring an ether cross-link and a C–C cross-link,
and both cross-links are installed by a radical S-adenosylmethionine (rSAM) enzyme DarE …

The necessity for the discovery of innovative antimicrobials to treat life-threatening diseases
has increased as multidrug-resistant bacteria has spread. Due to antibiotics' availability over …

There is a lack of new antibiotics to combat drug-resistant bacterial infections that
increasingly threaten global health. The current pipeline of clinical-stage antimicrobials is …

Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a
chemically diverse class of metabolites. Many RiPPs show potent biological activities that …

The β‐barrel assembly machinery (BAM complex) is essential for outer membrane protein
(OMP) folding in Gram‐negative bacteria, and represents a promising antimicrobial target …

Covering: 2016 to 2023 Ribosomally synthesized and posttranslationally modified peptides
(RiPPs) continue to be a rich source of chemically diverse and bioactive peptide natural …

Covering: up to March 2024. Microbial natural products have historically been a cornerstone
for the discovery of therapeutic agents. Advanced (meta) genome sequencing technologies …