Parkinson's disease (PD) is a progressive neurodegenerative disorder that lacks effective
treatment strategies to halt or delay its progression. The homeostasis of Ca2+ ions is crucial …

In situ physiological signals of in vitro neural disease models are essential for studying
pathogenesis and drug screening. Currently, an increasing number of in vitro neural disease …

Understanding medium spiny neuron (MSN) physiology is essential to understand motor
impairments in Parkinson's disease (PD) given the architecture of the basal ganglia. Here …

SARM1 is a key regulator of a conserved program of axon degeneration increasingly linked
to human neurodegenerative diseases. Pathological SARM1 activation causes rapid NAD …

Parkinson's disease (PD) is a complex neurodegenerative disease characterized by the
progressive loss of dopaminergic neurons in the substantia nigra and the widespread …

Midbrain dopaminergic (mDA) neurons are significantly impaired in patients inflicted with
Parkinson's disease (PD), subsequently affecting a variety of motor functions. There are four …

As our population ages, there is an increased unmet clinical need surrounding
neurodegenerative diseases such as Parkinson's disease (PD). To tackle this ever …

Parkinson's disease (PD) is characterized by the slow and progressive demise of dopamine
(DA)-synthesizing neurons in the substantia nigra pars compacta (SNc), a nucleus located in …

Neurodegenerative diseases represent a significant challenge to modern medicine, with
their complex etiology and progressive nature posing hurdles to effective treatment …

Neurodegenerative diseases pose significant challenges to healthcare systems globally due
to their complex etiology and relentless progression, often rendering conventional …