Approaches to investigate tissue-resident innate lymphocytes metabolism at the single-cell level
Tissue-resident innate immune cells have important functions in both homeostasis and
pathological states. Despite advances in the field, analyzing the metabolism of tissue …
pathological states. Despite advances in the field, analyzing the metabolism of tissue …
Unravelling metabolic factors impacting iNKT cell biology in obesity
C Wilkin, J Piette, S Legrand-Poels - Biochemical Pharmacology, 2024 - Elsevier
Obesity and related diseases have reached epidemic proportions and continue to rise.
Beyond creating an economical burden, obesity and its co-morbidities are associated with …
Beyond creating an economical burden, obesity and its co-morbidities are associated with …
[HTML][HTML] IFN-γ-dependent regulation of intestinal epithelial homeostasis by NKT cells
M Lebrusant-Fernandez, T Ap Rees, R Jimeno… - Cell Reports, 2024 - cell.com
Intestinal homeostasis is maintained through the combined functions of epithelial and
immune cells that collaborate to preserve the integrity of the intestinal barrier. However, the …
immune cells that collaborate to preserve the integrity of the intestinal barrier. However, the …
Insights into the heterogeneity of iNKT cells: tissue-resident and circulating subsets shaped by local microenvironmental cues
G Cui, S Abe, R Kato, K Ikuta - Frontiers in Immunology, 2024 - frontiersin.org
Invariant natural killer T (iNKT) cells are a distinct subpopulation of innate-like T
lymphocytes. They are characterized by semi-invariant T cell receptors (TCRs) that …
lymphocytes. They are characterized by semi-invariant T cell receptors (TCRs) that …
Contribution of NKT cells and CD1d-expressing cells in obesity-associated adipose tissue inflammation
M Satoh, K Iwabuchi - Frontiers in Immunology, 2024 - frontiersin.org
Natural killer T (NKT) cell are members of the innate-like T lymphocytes and recognizes lipid
antigens presented by CD1d-expressing cells. Obesity-associated inflammation in adipose …
antigens presented by CD1d-expressing cells. Obesity-associated inflammation in adipose …
T cell metabolism in kidney immune homeostasis
Z Liu, B Dai, J Bao, Y Pan - Frontiers in Immunology, 2024 - frontiersin.org
Kidney immune homeostasis is intricately linked to T cells. Inappropriate differentiation,
activation, and effector functions of T cells lead to a spectrum of kidney disease. While …
activation, and effector functions of T cells lead to a spectrum of kidney disease. While …
Lipid accumulation in adipose tissue-resident iNKT cells contributes to an inflammatory phenotype
I Morris, F Vrieling, A Bouwman, R Stienstra… - Adipocyte, 2024 - Taylor & Francis
Reciprocal communication between adipocytes and immune cells is essential to maintain
optimal adipose tissue (AT) functionality. Amongst others, adipocytes directly interact with …
optimal adipose tissue (AT) functionality. Amongst others, adipocytes directly interact with …
Control of the Development, Distribution, and Function of Innate-Like Lymphocytes and Innate Lymphoid Cells by the Tissue Microenvironment
Recently, considerable attention has been directed toward innate-like T cells (ITCs) and
innate lymphoid cells (ILCs) owing to their indispensable contributions to immune …
innate lymphoid cells (ILCs) owing to their indispensable contributions to immune …