Synopsis Mefloquine is an orally administered blood schizontocide. Initial dose-finding and
comparative studies performed between 1977 and 1989 demonstrated efficacy of …

Potassium inward rectifier channel Kir2 is an important component of terminal cardiac
repolarization and resting membrane stability. This functionality is part of balanced cardiac …

Although chloroquine remains an important therapeutic agent for treatment of malaria in
many parts of the world, its safety margin is very narrow. Chloroquine inhibits the cardiac …

Parasitic infections such as malaria, schistosomiasis, trypanosomiasis and onchoceriasis
are the scourge of the tropical countries. Many of the drugs used for the treatment of tropical …

The correlation ofP. falciparumlactate dehydrogenase (pLDH) activities and patent infections
was evaluated for monitoring therapeutic responses and drug resistance in 70 patients with …

The prevalence of Plasmodium falciparum parasitaemia was evaluated in 59 neonates
admitted to the University College Hospital, Ibadan in South-western Nigeria between …

Chlorpheniramine, a histamine H1 receptor antagonist, reverses chloroquine resistance in
Plasmodium falciparum in vitro. However, the clinical significance of this remains unclear …

In an area where multi-drug resistance in Plasmodium falciparum is a particular problem,
more than 500 children under 5 years of age weighing> 5 kg were treated with mefloquine …

The rapid dissemination of chloroquine-resistant Plasmodium falciparum in West Africa has
been well documented and represents a significant health threat to autochthonous …

Background Use of anti-malarial medication in children is hampered by a paucity of dosage,
pharmacokinetic and tolerability data. Methods Data on the use of mefloquine in children …