A historical perspective on estradiol's enhancement of cognitive function is presented, and
research, primarily in animals, but also in humans, is reviewed. Data regarding the …

Sex differences in neurological disease extend from incidence, severity, progression and
symptoms and may ultimately influence treatment. Cognitive disturbances are frequent in …

Although there is now a substantial literature on the putative neuroprotective effects of
estrogen on cognitive functioning in postmenopausal women, it is replete with …

In addition to modulating memory per se, estrogen alters the learning strategy used to solve
a task, thereby regulating the quality of information processed by the brain. This review …

Sex differences in brain and behavior are ubiquitous in sexually reproducing species.
Developmental differences in circulating concentrations of gonadal steroids underlie many …

This article is part of a Special Issue “Estradiol and cognition”. Estrogens are becoming well
known for their robust enhancement on cognition particularly for learning and memory that …

Physiologically high levels of circulating estradiol enhance the use of place learning and
impair the use of response learning to find food on a land maze. These two types of learning …

While some research has indicated that ovarian hormone therapy (HT) benefits memory and
decreases risk of Alzheimer's disease in menopausal women, several newer studies have …

The results of clinical and basic research conducted over the past two decades have
implicated a role for oestrogen in modulating cognitive function. This review focuses on what …

Alzheimer's disease (AD) is the leading cause of dementia in the elderly. Mutations in genes
encoding proteins involved in amyloid-β peptide (Aβ) production are responsible for …