By the introduction of technological advancement in methods of structural analysis,
electronics, and recombinant DNA techniques, research in physiology has become …

Familial disorders of skeletal muscle excitability were initially described early in the last
century and are now known to be caused by mutations of voltage-gated ion channels. The …

Ion channels are membrane proteins that act as gated pathways for the movement of ions
across cell membranes. They play essential roles in the physiology of all cells. In recent …

Ion channels serve many functions apart from electrical signal transduction: chemical
signalling (Ca2+ as a second messenger), transepithelial transport, regulation of …

Epilepsy is a common neurological condition that reflects neuronal hyperexcitability arising
from largely unknown cellular and molecular mechanisms. In generalized epilepsy with …

The Na V 1.4 sodium channel is highly expressed in skeletal muscle, where it carries almost
all of the inward Na+ current that generates the action potential, but is not present at …

Cannabidiol (CBD) is the primary nonpsychotropic phytocannabinoid found in Cannabis
sativa, which has been proposed to be therapeutic against many conditions, including …

The congenital long QT syndrome (LQTS) is an inherited disorder characterized by a
prolonged cardiac action potential. This delay in cellular repolarization can lead to …

Mutations in the adult human skeletal muscle Na+ channel a subunit cause the disease
paramyotonia congenita. Two paramyotonia congenita mutations, R1448H and R1448C …

Evidence accumulated over recent years has shown that genetic neurological
channelopathies can cause many different neurological diseases. Presentations relating to …