Glutathione and glutathione-related enzymes are pivotal for the normal functioning of
several important biological processes in humans. Glutathione and glutathione-related …

Pregnant mothers are exposed to a wide variety of foreign chemicals. This exposure is most
commonly due to maternal medication, lifestyle factors, such as smoking, drug abuse, and …

During past decades, knowledge on placental drug metabolism and mechanisms of
placental transfer has increased significantly. Most pharmaceutical drugs administered …

The human placenta oxidizes several xenobiotics, although the spectrum of substrates and
metabolic activities when compared with the liver appears restricted. Maternal cigarette …

This study was designed to analyze the effect of environmental oxidative stress on human
placental monooxygenases, glutathione S-transferase (GST) activity and polycyclic aromatic …

We evaluated the impact of maternal drug abuse at term on human placental cytochrome
P450 (CYP)-mediated (Phase I) xenobiotic and steroid-metabolizing activities [aromatase, 7 …

Severe pre-eclampsia reduced significantly (P< 0.05) by 68±6 per cent (mean±sem, n= 10)
the maximal velocity (Vmax) and, consequently, reduced significantly by 60±7 per cent the …

Evidence indicates that fetuses and infants are more vulnerable to environmental toxicants
than adults. The placenta is unique in that it is an organ that originates as a response to …

Radiation-induced peculiarities of cytochrome P-450IIE1 and oncogenes mRNA accumulation
in different rat tissues Page 68 Page 1 ISSN 0233-7657. Биополимеры и клетка. 1998. Т …

: Background: Buthionine sulfoximine is an agent that reduces intracellular glutathione and
anti-oxidant enzymes and by this means is involved in pathology of some disease. Since low …