The dosage of the serine threonine kinase DYRK1A is critical in the central nervous system
(CNS) during development and aging. This review analyzes the functions of this kinase by …

Control of organ size is of fundamental importance and is controlled by genetic,
environmental, and mechanical factors. Studies in many species have pointed to the …

The skin is a squamous epithelium that is continuously renewed by a population of basal
layer stem/progenitor cells and can heal wounds. Here, we show that the transcription …

Mechanical forces have been proposed to modulate organ growth, but a molecular
mechanism that links them to growth regulation in vivo has been lacking. We report that …

The Hippo signal transduction pathway is an important regulator of organ growth and cell
differentiation, and its deregulation contributes to the development of cancer. The activity of …

The YAP/TAZ family of transcriptional co‐activators drives cell proliferation in epithelial
tissues and cancers. Yet, how YAP and TAZ are physiologically regulated remains unclear …

Animal cells are thought to sense mechanical forces via the transcriptional co-activators YAP
(or YAP1) and TAZ (or WWTR1), the sole Drosophila homolog of which is named Yorkie …

ABSTRACT DYRK1A is important in neuronal development and function, and its excessive
activity is considered a significant pathogenic factor in Down syndrome and Alzheimer's …

DYRK1A (dual-specificity tyrosine-regulated kinase 1A) is a kinase with multiple implications
for embryonic development, especially in the nervous system where it regulates the balance …

The Hippo pathway is a conserved and critical regulator of tissue growth. The FERM protein
Expanded is a key signaling hub that promotes activation of the Hippo pathway, thereby …