The stereocontrolled construction of C− C bonds remains one of the foremost challenges in
organic synthesis. At the heart of any chemical synthesis of a natural product or designed …

Tremendous advances have been made in nickel catalysis over the past decade. Several
key properties of nickel, such as facile oxidative addition and ready access to multiple …

Conspectus Activation of inert chemical bonds, such as C–H, C–O, C–C, and so on, is a very
important area, to which has been drawn much attention by chemists for a long time and …

Amides have been widely studied for decades, but their synthetic utility has remained limited
in reactions that proceed with rupture of the amide C–N bond. Using Ni catalysis, we have …

Metal-catalyzed cross-couplings represent one of the most important reaction platforms in
modern synthetic chemistry (Figure 1 A). 1 Although the field enjoys a rich history, there …

Catalytic transformation of alcohols via metal-catalyzed cross-coupling reactions is very
important, but it typically relies on a multistep procedure. We here report a dynamic kinetic …

The asymmetric cross-coupling reaction is developed as a straightforward strategy toward 1,
1-diaryl alkanes, which are a key skeleton in a series of natural products and bioactive …

An asymmetric Ni-catalyzed reductive cross-coupling of (hetero) aryl iodides and benzylic
chlorides has been developed to prepare enantioenriched 1, 1-diarylalkanes. As part of …

The cross-coupling of boronic acids and related derivatives with sp 2 electrophiles (the
Suzuki–Miyaura reaction) is one of the most powerful C–C bond formation reactions in …

Alkyl oxalates, prepared from their corresponding alcohols, are engaged for the first time as
carbon radical fragments in metallaphotoredox catalysis. In this report, we demonstrate that …