A20 (also known as TNFAIP3) is a potent anti-inflammatory signalling molecule that restricts
multiple intracellular signalling cascades. Recent studies in three general areas have …

The small protein ubiquitin is a central regulator of a cell's life and death. Ubiquitin is best
known for targeting protein destruction by the 26S proteasome. In the past few years …

The functional maturation and preservation of hepatic cells derived from human induced
pluripotent stem cells (hiPSCs) are essential to personalized in vitro drug screening and …

Immune recognition of pathogen-associated molecular patterns (PAMPs) by pattern
recognition receptors often activates proinflammatory NF-κB signalling. Recent studies …

The pathophysiology of sepsis and septic shock involves complex cytokine and
inflammatory mediator networks. NF-κB activation is a central event leading to the activation …

Sepsis is the systemic immune response to severe bacterial infection. The innate immune
recognition of bacterial and viral products is mediated by a family of transmembrane …

Transcription factors of the NF-κB family regulate hundreds of genes in the context of
multiple important physiological and pathological processes. NF-κB activation depends on …

Toll-like receptors (TLRs) as well as the receptors for tumor necrosis factor (TNF-R) and
interleukin-1 (IL-1R) play an important role in innate immunity by regulating the activity of …

The gut barrier plays an important role in human health. When barrier function is impaired,
altered permeability and barrier dysfunction can occur, leading to inflammatory bowel …

Atherosclerosis underlies the leading cause of death in industrialized countries. 1
Atherosclerosis is a maladaptive, nonresolving chronic inflammatory disease that occurs …