European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender
TT Seppälä, A Latchford, I Negoi… - British Journal of …, 2021 - academic.oup.com
Background Lynch syndrome is the most common genetic predisposition for hereditary
cancer but remains underdiagnosed. Large prospective observational studies have recently …
cancer but remains underdiagnosed. Large prospective observational studies have recently …
Microsatellite instability and immune checkpoint inhibitors: toward precision medicine against gastrointestinal and hepatobiliary cancers
Y Eso, T Shimizu, H Takeda, A Takai… - Journal of …, 2020 - Springer
Recent innovations in the next-generation sequencing technologies have unveiled that the
accumulation of genetic alterations results in the transformation of normal cells into cancer …
accumulation of genetic alterations results in the transformation of normal cells into cancer …
Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database
Purpose Pathogenic variants affecting MLH1, MSH2, MSH6, and PMS2 cause Lynch
syndrome and result in different but imprecisely known cancer risks. This study aimed to …
syndrome and result in different but imprecisely known cancer risks. This study aimed to …
Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database
P Møller, TT Seppälä, I Bernstein, E Holinski-Feder… - Gut, 2018 - gut.bmj.com
Background Most patients with path_MMR gene variants (Lynch syndrome (LS)) now
survive both their first and subsequent cancers, resulting in a growing number of older …
survive both their first and subsequent cancers, resulting in a growing number of older …
Guidelines for the management of hereditary colorectal cancer from the British Society of Gastroenterology (BSG)/Association of Coloproctology of Great Britain and …
KJ Monahan, N Bradshaw, S Dolwani, B Desouza… - Gut, 2020 - gut.bmj.com
Heritable factors account for approximately 35% of colorectal cancer (CRC) risk, and almost
30% of the population in the UK have a family history of CRC. The quantification of an …
30% of the population in the UK have a family history of CRC. The quantification of an …
[HTML][HTML] Delphi initiative for early-onset colorectal cancer (DIRECt) international management guidelines
GM Cavestro, A Mannucci, F Balaguer… - Clinical …, 2023 - Elsevier
Background & Aims Patients with early-onset colorectal cancer (eoCRC) are managed
according to guidelines that are not age-specific. A multidisciplinary international group …
according to guidelines that are not age-specific. A multidisciplinary international group …
[HTML][HTML] Hereditary gastrointestinal cancers: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
N Stjepanovic, L Moreira, F Carneiro, F Balaguer… - Annals of …, 2019 - Elsevier
Knowledge of genetic susceptibility to gastrointestinal cancers is constantly evolving with
identification of new genes. Similarly, a better understanding of the genotype/phenotype …
identification of new genes. Similarly, a better understanding of the genotype/phenotype …
Hereditary breast cancer: syndromes, tumour pathology and molecular testing
A Sokolova, KJ Johnstone, AE McCart Reed… - …, 2023 - Wiley Online Library
Hereditary factors account for a significant proportion of breast cancer risk. Approximately
20% of hereditary breast cancers are attributable to pathogenic variants in the highly …
20% of hereditary breast cancers are attributable to pathogenic variants in the highly …
Association of patient comorbid conditions with cancer clinical trial participation
Importance The American Society of Clinical Oncology (ASCO), Friends of Cancer
Research, and the US Food and Drug Administration recently recommended modernizing …
Research, and the US Food and Drug Administration recently recommended modernizing …
Recent advances in Lynch syndrome
LH Biller, S Syngal, MB Yurgelun - Familial cancer, 2019 - Springer
Lynch syndrome is one of the most common hereditary cancer predisposition syndromes
and is associated with increased risks of colorectal and endometrial cancer, as well as …
and is associated with increased risks of colorectal and endometrial cancer, as well as …