Ultraviolet radiations: Skin defense-damage mechanism
UV-radiations are the invisible part of light spectra having a wavelength between visible rays
and X-rays. Based on wavelength, UV rays are subdivided into UV-A (320–400 nm), UV-B …
and X-rays. Based on wavelength, UV rays are subdivided into UV-A (320–400 nm), UV-B …
Pathogenesis of systemic lupus erythematosus
The exact patho-aetiology of systemic lupus erythematosus (SLE) remains elusive. An
extremely complicated and multifactorial interaction among various genetic and …
extremely complicated and multifactorial interaction among various genetic and …
Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes.
Systemic lupus erythematosus is a multisystem autoimmune disease in which the
autoantibody response targets a variety of autoantigens of diverse subcellular location. We …
autoantibody response targets a variety of autoantigens of diverse subcellular location. We …
TRIM21/Ro52-roles in innate immunity and autoimmune disease
TRIM21 (Ro52/SSA1) is an E3 ubiquitin ligase with key roles in immune host defence, signal
transduction, and possibly cell cycle regulation. It is also an autoantibody target in Sjögren's …
transduction, and possibly cell cycle regulation. It is also an autoantibody target in Sjögren's …
Serology of lupus erythematosus: correlation between immunopathological features and clinical aspects
E Cozzani, M Drosera, G Gasparini… - Autoimmune …, 2014 - Wiley Online Library
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the
aberrant production of a broad and heterogenous group of autoantibodies. Even though the …
aberrant production of a broad and heterogenous group of autoantibodies. Even though the …
Light, including ultraviolet
E Maverakis, Y Miyamura, MP Bowen, G Correa… - Journal of …, 2010 - Elsevier
Ultraviolet (UV) light is intricately linked to the functional status of the cutaneous immune
system. In susceptible individuals, UV radiation can ignite pathogenic inflammatory …
system. In susceptible individuals, UV radiation can ignite pathogenic inflammatory …
New insights into mechanisms of therapeutic effects of antimalarial agents in SLE
DJ Wallace, VS Gudsoorkar, MH Weisman… - Nature Reviews …, 2012 - nature.com
Antimalarial agents have routinely been used for the treatment of systemic lupus
erythematosus (SLE) for over 50 years. These agents continue to enjoy success as the initial …
erythematosus (SLE) for over 50 years. These agents continue to enjoy success as the initial …
Clearance deficiency and systemic lupus erythematosus (SLE)
Systemic lupus erythematosus (SLE) is a fairly heterogeneous autoimmune disease.
Impaired clearance functions for dying cells may explain accumulation of nuclear …
Impaired clearance functions for dying cells may explain accumulation of nuclear …
Anti-ro/ssa and la/ssb antibodies
F Franceschini, I Cavazzana - Autoimmunity, 2005 - Taylor & Francis
The Ro/La system is considered as an heterogeneous antigenic complex, constituted by
three different proteins (52 kDa Ro, 60 kDa Ro and La) and four small RNAs particles. Anti …
three different proteins (52 kDa Ro, 60 kDa Ro and La) and four small RNAs particles. Anti …
Neonatal lupus: follow-up in infants with anti-SSA/Ro antibodies and review of the literature
AA Zuppa, R Riccardi, S Frezza, F Gallini… - Autoimmunity …, 2017 - Elsevier
Abstract Neonatal Lupus Syndrome (NLS) is a distinct clinical entity caused by
transplacental passage of maternal anti-SSA/Ro antibodies (Ab). Mothers may have …
transplacental passage of maternal anti-SSA/Ro antibodies (Ab). Mothers may have …