Immune-related adverse events of checkpoint inhibitors

M Ramos-Casals, JR Brahmer, MK Callahan… - Nature reviews Disease …, 2020 - nature.com
Cancer immunotherapies have changed the landscape of cancer treatment during the past
few decades. Among them, immune checkpoint inhibitors, which target PD-1, PD-L1 and …

Immune-related toxicities of checkpoint inhibitors: mechanisms and mitigation strategies

RJ Sullivan, JS Weber - Nature reviews Drug discovery, 2022 - nature.com
The immune-related adverse events associated with treatment with immune checkpoint
inhibitors result in significant morbidity for patients as well as considerable cost to the health …

Management of immune-related adverse events in patients treated with immune checkpoint inhibitor therapy: ASCO guideline update

BJ Schneider, J Naidoo, BD Santomasso… - Journal of Clinical …, 2021 - ascopubs.org
PURPOSE To increase awareness, outline strategies, and offer guidance on the
recommended management of immune-related adverse events (irAEs) in patients treated …

Adverse effects of immune-checkpoint inhibitors: epidemiology, management and surveillance

F Martins, L Sofiya, GP Sykiotis, F Lamine… - Nature reviews Clinical …, 2019 - nature.com
Abstract Immune-checkpoint inhibitors (ICIs), including anti-cytotoxic T lymphocyte antigen 4
(CTLA-4), anti-programmed cell death 1 (PD-1) and anti-programmed cell death 1 ligand 1 …

Management of immune-related adverse events in patients treated with immune checkpoint inhibitor therapy: American Society of Clinical Oncology Clinical Practice …

JR Brahmer, C Lacchetti, BJ Schneider… - Journal of Clinical …, 2018 - ascopubs.org
Purpose To increase awareness, outline strategies, and offer guidance on the
recommended management of immune-related adverse events in patients treated with …

Management of immunotherapy-related toxicities, version 1.2019, NCCN clinical practice guidelines in oncology

JA Thompson, BJ Schneider, J Brahmer… - Journal of the National …, 2019 - jnccn.org
The aim of the NCCN Guidelines for Management of Immunotherapy-Related Toxicities is to
provide guidance on the management of immune-related adverse events resulting from …

Current diagnosis and management of immune related adverse events (irAEs) induced by immune checkpoint inhibitor therapy

V Kumar, N Chaudhary, M Garg, CS Floudas… - Frontiers in …, 2017 - frontiersin.org
The indications of immune checkpoint inhibitors (ICIs) are set to rise further with the approval
of newer agent like atezolimumab for use in patients with advanced stage urothelial …

[HTML][HTML] Neurological adverse events associated with immune checkpoint inhibitors: review of the literature

S Cuzzubbo, F Javeri, M Tissier, A Roumi… - European Journal of …, 2017 - Elsevier
Immune checkpoint inhibitors (ICIs) targeting CTLA4 and PD1 constitute a promising class of
cancer treatment but are associated with several immune-related disorders. We here review …

Profiling preexisting antibodies in patients treated with anti–PD-1 therapy for advanced non–small cell lung cancer

Y Toi, S Sugawara, J Sugisaka, H Ono… - JAMA …, 2019 - jamanetwork.com
Importance Administration of anti–programmed cell death protein 1 (anti–PD-1) is now
standard therapy in advanced non–small cell lung cancer (NSCLC). However, immune …

Glial fibrillary acidic protein immunoglobulin G as biomarker of autoimmune astrocytopathy: analysis of 102 patients

EP Flanagan, SR Hinson, VA Lennon… - Annals of …, 2017 - Wiley Online Library
Objective A novel autoimmune central nervous system (CNS) disorder with glial fibrillary
acidic protein (GFAP)‐IgG as biomarker was recently characterized. Here, 102 patients with …