Over the past decade, methods for predicting three-dimensional (3-D) chromosome and
genome structures have proliferated. This has been primarily due to the development of high …

Integrative modeling is an increasingly important tool in structural biology, providing
structures by combining data from varied experimental methods and prior information. As a …

The sequence of a genome is insufficient to understand all genomic processes carried out in
the cell nucleus. To achieve this, the knowledge of its three-dimensional architecture is …

Chromosome organization is crucial for genome function. Here, we present a method for
visualizing chromosomal DNA at super-resolution and then integrating Hi-C data to produce …

Biophysicists are modeling conformations of interphase chromosomes, often basing the
strengths of interactions between segments distant on the genetic map on contact …

To investigate the three-dimensional (3D) genome architecture across normal B cell
differentiation and in neoplastic cells from different subtypes of chronic lymphocytic leukemia …

Essential processes in biology are carried out by large macromolecular assemblies, whose
structures are often difficult to determine by traditional methods. Increasingly, researchers …

DNA-binding proteins are central regulators of chromosome organization; however, in
genome-reduced bacteria their diversity is largely diminished. Whether the chromosomes of …

Chromosome conformation capture technologies that provide frequency information for
contacts between genomic regions have been crucial for increasing our understanding of …

Chromosomes are large polymer molecules composed of nucleotides. In some species,
such as humans, this polymer can sum up to meters long and still be properly folded within …