Nitric oxide (NO) signalling has pleiotropic roles in biology and a crucial function in
cardiovascular homeostasis. Tremendous knowledge has been accumulated on the …

Type 2 diabetes mellitus (T2DM) is characterised by chronic low-grade inflammation,
recently referred to as 'metaflammation', a relevant factor contributing to the development of …

Abstract Background Type 2 diabetes (T2D) is associated with generalized vascular
dysfunction characterized by increases in large artery stiffness, endothelial dysfunction, and …

microRNAs (miRNAs) are a class of small non-coding endogenous RNA molecules that
regulate a wide range of biological processes by post-transcriptionally regulating gene …

Type 2 diabetes mellitus (DM) is a common metabolic disorder predisposing to diabetic
cardiomyopathy and atherosclerotic cardiovascular disease (CVD), which could lead to …

Osteoarthritis (OA) is a common, painful disease. Currently OA is incurable, and its etiology
largely unknown, partly due to limited understanding of OA as a whole-joint disease. Here …

The gut microbiome has emerged as a critical regulator of human physiology. Deleterious
changes to the composition or number of gut bacteria, commonly referred to as gut …

Key points Age‐related arterial dysfunction, characterized by oxidative stress‐and
inflammation‐mediated endothelial dysfunction and arterial stiffening, is the primary risk …

Aims Our previous study demonstrated that Ca2+ influx through the Orai1 store-operated
Ca2+ channel in macrophages contributes to foam cell formation and atherosclerosis via the …

Chronic, low-grade systemic inflammation and impaired microvascular function are critical
hallmarks in the development of insulin resistance. Accordingly, insulin resistance is a major …