The assembly of ribosomal subunits is a highly orchestrated process that involves a huge
cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified …

In the past 25 years, genetic and biochemical analyses of ribosome assembly in yeast have
identified most of the factors that participate in this complex pathway and have generated …

Ribosomes are highly conserved ribonucleoprotein nanomachines that translate information
in the genome to create the proteome in all cells. In yeast these complex particles contain …

Abstract Box C/D and H/ACA RNPs are essential ribonucleoprotein particles that are found
throughout both eukaryotes [small nucleolar RNPs (snoRNPs)] and archaea [snoRNP‐like …

Several types of pediatric cancers reportedly contain high-frequency missense mutations in
histone H3, yet the underlying oncogenic mechanism remains poorly characterized. Here …

The 90S pre-ribosome is an early biogenesis intermediate formed during co-transcriptional
ribosome formation, composed of∼ 70 assembly factors and several small nucleolar RNAs …

The nucleolus is a large nuclear domain in which transcription, maturation and assembly of
ribosomes take place. In higher eukaryotes, nucleolar organization in three sub-domains …

RNA fate and function are affected by their structures and interactomes. However, how RNA
and RNA-binding proteins (RBPs) assemble into higher-order structures and how RNA …

Eukaryotic small ribosomal subunits are first assembled into 90S pre-ribosomes. The
complete 90S is a gigantic complex with a molecular mass of approximately five …

The coordinated integration of ribosomal RNA and protein into two functional ribosomal
subunits is safeguarded by quality control checkpoints that ensure ribosomes are correctly …