Therapeutic strategies to ameliorate neuronal damage in epilepsy by regulating oxidative stress, mitochondrial dysfunction, and neuroinflammation

S Madireddy, S Madireddy - Brain sciences, 2023 - mdpi.com
Epilepsy is a central nervous system disorder involving spontaneous and recurring seizures
that affects 50 million individuals globally. Because approximately one-third of patients with …

[HTML][HTML] Molecular insights into the pathogenic impact of vitamin D deficiency in neurological disorders

MJ Anwar, SK Alenezi, AH Alhowail - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Neurological disorders are the major cause of disability, leading to a decrease in quality of
life by impairing cognitive, sensorimotor, and motor functioning. Several factors have been …

Vitamin D3 attenuates lipopolysaccharide-induced cognitive impairment in rats by inhibiting inflammation and oxidative stress

A Mokhtari-Zaer, M Hosseini, H Salmani, Z Arab… - Life sciences, 2020 - Elsevier
Aims Vitamin D is a well-known endocrine regulator of calcium/phosphate homeostasis and
has been reported as having a wide range of activities that are potentially beneficial for …

Vitamin D supplementation has no effect on cognitive performance after four months in mid-aged and older subjects

R Jorde, J Kubiak, J Svartberg, OM Fuskevåg… - Journal of the …, 2019 - Elsevier
Background Low serum 25-hydroxyvitamin D (25 (OH) D) levels are associated with
impaired cognitive function, but the effect of vitamin D supplementation on cognitive function …

Functional nutrients for epilepsy

JE Kim, KO Cho - Nutrients, 2019 - mdpi.com
Epilepsy is a common neurological disorder of which seizures are a core symptom.
Approximately one third of epileptic patients are resistant to antiepileptic drugs and therefore …

The effect of coenzyme Q10 on liver injury induced by valproic acid and its antiepileptic activity in rats

F Alqarni, HS Eweis, A Ali, A Alrafiah, M Alsieni… - Biomedicines, 2022 - mdpi.com
Valproic acid (VPA) has toxic metabolites that can elevate oxidative stress markers, and the
hepatotoxicity of VPA has been reported. Coenzyme Q10 (CoQ10) is one of the most widely …

Neuroinflammation impact in epileptogenesis and new treatment strategy

AM Mahfoz, N Shahzad - Behavioural pharmacology, 2019 - journals.lww.com
Epilepsy is considered a major serious chronic neurological disorder, characterized by
recurrent seizures. It is usually associated with a history of a lesion in the nervous system …

Effects of vitamin D on drugs: Response and disposal

J Peng, Y Liu, J Xie, G Yang, Z Huang - Nutrition, 2020 - Elsevier
Vitamin D supplementation and vitamin D deficiency are common in clinical experience and
in daily life. Vitamin D not only promotes calcium absorption and immune regulation, but …

Protective effect of cholecalciferol against cobalt-induced neurotoxicity in rats: ZO-1/iFABP, ChAT/AchE and antioxidant pathways as potential therapeutic targets

AS Akinrinde, BO Adeoye, ES Samuel… - … Trace Element Research, 2024 - Springer
Cobalt (Co) toxicity has been reported to produce central nervous system and
gastrointestinal abnormalities. This study assessed the therapeutic effect of cholecalciferol …

Molecular docking to investigate the inhibitory activity and the role of nitric oxide in anticonvulsant effects of vitamin D on pentylenetetrazole‑induced epileptic seizures …

R Akkaya, B Akkaya, RO Bello - Journal of Molecular Structure, 2023 - Elsevier
Despite the great breakthroughs in the field of epilepsy studies, the present drugs are
ineffective in one-third of the patients, as well as without providing a definite treatment. There …