Metabolic abnormalities such as dyslipidemia, hyperinsulinemia, or insulin resistance and
obesity play key roles in the induction and progression of type 2 diabetes mellitus (T2DM) …

Abstract More than 2.1 million age-related fractures occur in the United States annually,
resulting in an immense socioeconomic burden. Importantly, the age-related deterioration of …

Regenerating defective bone in patients with diabetes mellitus remains a significant
challenge due to high blood glucose level and oxidative stress. Here we aim to tackle this …

With the progress of the aging population, bone-related diseases such as osteoporosis and
osteoarthritis have become urgent problems. Recent studies have demonstrated the …

Background Diabetes mellitus (DM) is considered to be an important factor for bone
degeneration disorders such as bone defect nonunion, which is characterized by physical …

Bone fragility has been recognized as a complication of diabetes, both type 1 diabetes (T1D)
and type 2 diabetes (T2D), whereas the relationship between prediabetes and fracture risk …

In a large population-based study of Iran, the age-standardized prevalence of osteoporosis
was 24.6% in men and 62.7% in women aged≥ 60 years. Osteoporosis was negatively …

Objective To reveal the relationship between Body Mass Index (BMI), type 2 diabetes, and
bone mineral density (BMD) using a mendelian randomization (MR) approach. Methods …

Bone regeneration following trauma, tumor resection, infection, or congenital disease is
challenging. Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia …

It remains unclear whether the relationship between type 2 diabetes mellitus (T2DM) and
bone mineral density (BMD) reflects causality in East Asian populations. Herein, a …