Addressing blood-brain-tumor-barrier heterogeneity in pediatric brain tumors with innovative preclinical models

EK Morris, S Daignault-Mill, SJ Stehbens… - Frontiers in …, 2023 - frontiersin.org
Brain tumors represent the leading cause of disease-related mortality and morbidity in
children, with effective treatments urgently required. One factor limiting the effectiveness of …

Applications of CRISPR-Cas9 for advancing precision medicine in oncology: from target discovery to disease modeling

M Ravichandran, D Maddalo - Frontiers in Genetics, 2023 - frontiersin.org
The clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-
associated protein 9 (Cas9)(CRISPR/Cas9) system is a powerful tool that enables precise …

Progress in characterizing ABC multidrug transporters in zebrafish

JR Thomas, WJE Frye, RW Robey… - Drug Resistance …, 2024 - Elsevier
Zebrafish have proved to be invaluable for modeling complex physiological processes
shared by all vertebrate animals. Resistance of cancers and other diseases to drug …

[HTML][HTML] Identifying in vivo genetic dependencies of melanocyte and melanoma development

S Perlee, Y Ma, MV Hunter, JB Swanson, Z Ming, J Xia… - eLife, 2024 - elifesciences.org
The advent of large-scale sequencing in both development and disease has identified large
numbers of candidate genes that may be linked to important phenotypes. Validating the …

Zebrafish in Lung Cancer Research

X Wu, X Hua, K Xu, Y Song, T Lv - Cancers, 2023 - mdpi.com
Simple Summary Zebrafish is a crucial in vivo model for lung cancer research and is widely
employed in studies focusing on cancer proliferation, metastasis, and angiogenesis. It plays …

Developmental toxicity and mechanism of dibutyl phthalate on the development of subintestinal vessels in zebrafish

W Peng, X Yi, Y Peng, H Lu, H Liu - Scientific Reports, 2024 - nature.com
Background: The dibutyl phthalate (DBP) is a member of the phthalate family and is widely
used as a plasticizer in daily life and production. However, the influence of DBP on the …

Staphylococcus aureus lipid factors modulate melanoma cell clustering and invasion

MA Giese, G Ramakrishnan… - Disease Models & …, 2024 - journals.biologists.com
The microbiome can influence cancer development and progression. However, less is
known about the role of the skin microbiota in melanoma. Here, we took advantage of a …

[HTML][HTML] Small Fish, Big Answers: Zebrafish and the Molecular Drivers of Metastasis

MF Martínez-López, JF López-Gil - International Journal of Molecular …, 2025 - mdpi.com
Cancer metastasis is a leading cause of cancer-related deaths and represents one of the
most challenging processes to study due to its complexity and dynamic nature. Zebrafish …

Zebrafish: A Relevant Genetic Model for Human Primary Immunodeficiency (PID) Disorders?

F Basheer, R Sertori, C Liongue, AC Ward - International Journal of …, 2023 - mdpi.com
Primary immunodeficiency (PID) disorders, also commonly referred to as inborn errors of
immunity, are a heterogenous group of human genetic diseases characterized by defects in …

The Contribution of the Zebrafish Model to the Understanding of Polycomb Repression in Vertebrates

M Hanot, L Raby, P Völkel, X Le Bourhis… - International Journal of …, 2023 - mdpi.com
Polycomb group (PcG) proteins are highly conserved proteins assembled into two major
types of complexes, PRC1 and PRC2, involved in the epigenetic silencing of a wide range of …