Reactivity of acrylamides causes cytotoxicity and activates oxidative stress response

J Huchthausen, BI Escher, N Grasse… - Chemical research in …, 2023 - ACS Publications
Acrylamides are widely used industrial chemicals that cause adverse effects in humans or
animals, such as carcinogenicity or neurotoxicity. The excess toxicity of these reactive …

Characterization of primary glutathione conjugates with acrylamide and glycidamide: Toxicokinetic studies in Sprague Dawley rats treated with acrylamide

YS Luo, TY Long, SY Chiang, KY Wu - Chemico-Biological Interactions, 2021 - Elsevier
Acrylamide (AA) is classified as a probable human carcinogen and is ubiquitous in foods
processed at high temperatures. The carcinogenicity of AA has been attributed to its active …

2-Cyanopyrimidine-Containing Molecules for N-Terminal Selective Cyclization of Phage-Displayed Peptides

JT Hampton, CR Dobie, DD Coleman… - ACS Chemical …, 2025 - ACS Publications
Current methods for the macrocyclization of phage-displayed peptides often rely on small
molecule linkers that nonspecifically react with targeted amino acid residues. To expand tool …

Mechanistic evidence for the effect of sulphur-based additive: Methionine, on acrylamide reduction

DA Augustine, GA Bent, PN Nelson - Food Additives & …, 2021 - Taylor & Francis
The unavoidable presence of acrylamide in foods has fuelled the search for a suitable food
additive, one that can successfully mitigate dietary acrylamide levels without changing food …

Use of nucleophilic compounds, and their combination, for acrylamide removal

R Zamora, FJ Hidalgo - Acrylamide in Food, 2024 - Elsevier
Acrylamide is characterized by a conjugated structure in which an electron-withdrawing
group (the amide group) is linked to a carbon-carbon double bond. Therefore, this …

A DFT Study of the Reaction of Acrylamide with L-Cysteine and L-Glutathione

S Ramirez-Montes, LA Zárate-Hernández… - Molecules, 2022 - mdpi.com
Thermal processing of certain foods implies the formation of acrylamide, which has been
proven to provoke adverse effects on human health. Thus, several strategies to mitigate it …

A theoretical insight into the reaction mechanisms of a 2, 4, 6-trinitrotoluene nitroso metabolite with thiols for toxic effects

Y Zhou, X Liu, W Jiang, Y Shu, G Xu - Toxicology Research, 2019 - academic.oup.com
Abstract 2, 4, 6-Trinitrotoluene (TNT) is a class C carcinogen as rated by the Environmental
Protection Agency. One of the toxicity mechanisms of TNT is the covalent binding of its …

[PDF][PDF] Towards a Deeper Understanding of the Mechanisms of Interaction between Acrylamide and Key Body-Fluid Thiols

GA Bent, RA Fairman, L Grierson - J Clin Toxicol, 2016 - researchgate.net
Acrylamide (AA), is an α, β-unsaturated compound that is used mainly in the production of
polyacrylamide. Polyacrylamide is nontoxic and is used as a flocculant in water treatment …