Acromegaly: pathogenesis, diagnosis, and management

M Fleseriu, F Langlois, DST Lim… - The Lancet Diabetes & …, 2022 - thelancet.com
Growth hormone-secreting pituitary adenomas that cause acromegaly arise as monoclonal
expansions of differentiated somatotroph cells and are usually sporadic. They are almost …

A Consensus Statement on acromegaly therapeutic outcomes

S Melmed, MD Bronstein, P Chanson… - Nature Reviews …, 2018 - nature.com
Abstract The 11th Acromegaly Consensus Conference in April 2017 was convened to
update recommendations on therapeutic outcomes for patients with acromegaly. Consensus …

Systemic complications of acromegaly and the impact of the current treatment landscape: an update

MR Gadelha, L Kasuki, DST Lim… - Endocrine reviews, 2019 - academic.oup.com
Acromegaly is a chronic systemic disease with many complications and is associated with
increased mortality when not adequately treated. Substantial advances in acromegaly …

Acromegaly: an endocrine society clinical practice guideline

L Katznelson, ER Laws Jr, S Melmed… - The Journal of …, 2014 - academic.oup.com
Objective: The aim was to formulate clinical practice guidelines for acromegaly. Participants:
The Task Force included a chair selected by the Endocrine Society Clinical Guidelines …

[HTML][HTML] Acromegaly at diagnosis in 3173 patients from the Liège Acromegaly Survey (LAS) Database

P Petrossians, AF Daly, E Natchev… - Endocrine-related …, 2017 - ncbi.nlm.nih.gov
Acromegaly is a rare disorder caused by chronic growth hormone (GH) hypersecretion.
While diagnostic and therapeutic methods have advanced, little information exists on trends …

A consensus on criteria for cure of acromegaly

A Giustina, P Chanson, MD Bronstein… - The Journal of …, 2010 - academic.oup.com
Objective: The Acromegaly Consensus Group met in April 2009 to revisit the guidelines on
criteria for cure as defined in 2000. Participants: Participants included 74 neurosurgeons …

Expert consensus document: a consensus on the medical treatment of acromegaly

A Giustina, P Chanson, D Kleinberg… - Nature Reviews …, 2014 - nature.com
Abstract In March 2013, the Acromegaly Consensus Group met to revise and update
guidelines for the medical treatment of acromegaly. The meeting comprised experts skilled …

Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects

N Møller, JOL Jørgensen - Endocrine reviews, 2009 - academic.oup.com
In evolutionary terms, GH and intracellular STAT 5 signaling is a very old regulatory system.
Whereas insulin dominates periprandially, GH may be viewed as the primary anabolic …

Acromegaly pathogenesis and treatment

S Melmed - The Journal of clinical investigation, 2009 - Am Soc Clin Investig
Dysregulated growth hormone (GH) hypersecretion is usually caused by a GH-secreting
pituitary adenoma and leads to acromegaly—a disorder of disproportionate skeletal, tissue …

Guidelines for acromegaly management: an update

S Melmed, A Colao, A Barkan, M Molitch… - Journal of Clinical …, 2009 - cdr.lib.unc.edu
" Objective: The Acromegaly Consensus Group reconvened in November 2007 to update
guidelines for acromegaly management. Participants: The meeting participants comprised …