A guide to plasma membrane solute carrier proteins

MD Pizzagalli, A Bensimon… - The FEBS …, 2021 - Wiley Online Library
This review aims to serve as an introduction to the solute carrier proteins (SLC) superfamily
of transporter proteins and their roles in human cells. The SLC superfamily currently …

Pro‐and antioxidant effects of vitamin C in cancer in correspondence to its dietary and pharmacological concentrations

E Pawlowska, J Szczepanska… - Oxidative Medicine and …, 2019 - Wiley Online Library
Vitamin C is an antioxidant that may scavenge reactive oxygen species preventing DNA
damage and other effects important in cancer transformation. Dietary vitamin C from natural …

The role of vitamin C in cancer prevention and therapy: a literature review

M Villagran, J Ferreira, M Martorell, L Mardones - Antioxidants, 2021 - mdpi.com
Vitamin C is a water-soluble antioxidant associated with the prevention of the common cold
and is also a cofactor of hydrolases that participate in the synthesis of collagen and …

Aging and its treatment with vitamin C: a comprehensive mechanistic review

S Mumtaz, S Ali, HM Tahir, SAR Kazmi… - Molecular biology …, 2021 - Springer
Aging and age-related disorders have become one of the prominent issue of world.
Oxidative stress due to overproduction of reactive oxygen species is the most significant …

[HTML][HTML] Therapeutic use of vitamin C in cancer: physiological considerations

FJ Roa, E Peña, M Gatica, K Escobar-Acuña… - Frontiers in …, 2020 - frontiersin.org
Since the early studies of William J. McCormick in the 1950s, vitamin C has been proposed
as a candidate for the treatment of cancer. A number of reports have shown that …

Understanding breast cancer: From conventional therapies to repurposed drugs

B Costa, I Amorim, F Gärtner, N Vale - European Journal of Pharmaceutical …, 2020 - Elsevier
Breast cancer is the most common cancer among women and is considered a developed
country disease. Moreover, is a heterogenous disease, existing different types and stages of …

Vitamin C transporters and their implications in carcinogenesis

K Linowiecka, M Foksinski, AA Brożyna - Nutrients, 2020 - mdpi.com
Vitamin C is implicated in various bodily functions due to its unique properties in redox
homeostasis. Moreover, vitamin C also plays a great role in restoring the activity of 2 …

High-dose vitamin C: preclinical evidence for tailoring treatment in cancer patients

M Giansanti, T Karimi, I Faraoni, G Graziani - Cancers, 2021 - mdpi.com
Simple Summary Vitamin C is an indispensable micronutrient in the human diet due to the
multiple functions it carries out in the body. Reports of clinical studies have indicated that …

Redox modifications of cysteine-containing proteins, cell cycle arrest and translation inhibition: involvement in vitamin C-induced breast cancer cell death

N El Banna, E Hatem, A Heneman-Masurel, T Léger… - Redox biology, 2019 - Elsevier
Vitamin C (VitC) possesses pro-oxidant properties at high pharmacologic concentrations
which favor repurposing VitC as an anti-cancer therapeutic agent. However, redox-based …

Vitamin C inhibits the growth of colorectal cancer cell HCT116 and reverses the glucose-induced oncogenic effect by downregulating the Warburg effect

C Yu, S Min, F Lv, L Ren, Y Yang, L Chen - Medical Oncology, 2023 - Springer
Malnutrition caused by insufficient nutritional supply may significantly hinder the quality of
life among cancer patients. Sugar provides energy and nutritional support, but it also …