Liquid chromatography–tandem mass spectrometry for rapid and selective simultaneous determination of fluoroquinolones level in human aqueous humor

AA Alhusban, OA Tarawneh, SO Dawabsheh… - … of Pharmacological and …, 2019 - Elsevier
Endophthalmitis, an intraocular infection, may lead to irreversible loss of vision.
Antimicrobial chemotherapy is prescribed prior to ocular surgical procedures to avoid …

Structure, Solubility and Stability of Orbifloxacin Crystal Forms: Hemihydrate versus Anhydrate

OMM Santos, JTJ Freitas, ECL Cazedey, MB Araújo… - Molecules, 2016 - mdpi.com
Orbifloxacin (ORBI) is a widely used antimicrobial drug of the fluoroquinolone class. In the
official pharmaceutical compendia the existence of polymorphism in this active …

Pharmacokinetics of orbifloxacin in crucian carp (Carassius auratus) after intravenous and intramuscular administration

F Yang, F Yang, G Wang, W Shi, T Kong… - Journal of veterinary …, 2018 - Wiley Online Library
The pharmacokinetics of orbifloxacin was studied after a single dose (7.5 mg/kg) of
intravenous or intramuscular administration to crucian carp (Carassius auratus) reared in …

Development of a multiroute physiologically based pharmacokinetic model for orbifloxacin in rabbits

F Yang, F Yang, W Shi, H Si, T Kong… - Journal of veterinary …, 2018 - Wiley Online Library
To predict the orbifloxacin concentrations in rabbits after multiple routes of administration, a
flow‐limited multiroute physiologically based pharmacokinetic (PBPK) model was …

Pharmacokinetics of orbifloxacin in mehsana goats after intravenous and intramuscular administration.

D Ghanshyam, A Avinash, K Divyesh, A Madhavi… - 2015 - cabidigitallibrary.org
Single-dose pharmacokinetics of orbifloxacin (2.5 mg/kg bodyweight) were determined in
clinically normal female mehsana goats (n= 6) following intravenous and intramuscular …

Formas sólidas no melhoramento das propriedades físico-químicas de fármacos de baixa solubilidade aquosa: doxiciclina, orbifloxacino e carvedilol

OMMS VIANA - 2016 - bdtd.unifal-mg.edu.br
RESUMO Vários Ingredientes Farmacêuticos Ativos (IFAs)(do inglês: Active Pharmaceutical
Ingredients) descritos na Farmacopeia Americana são de baixa solubilidade aquosa ou …

慢性腎臓病の犬における血中オルビフロキサシン濃度の評価

船山麻理菜, 上地正実 - 日本獣医師会雑誌, 2014 - jstage.jst.go.jp
抄録 オルビフロキサシンは濃度依存的に殺菌活性を示す動物用フルオロキノロン系抗菌薬であり,
おもに腎臓から排泄される. 本研究では, 慢性腎臓病 (Chronic Kidney Disease: CKD) …