Prolyl hydroxylase domain oxygen sensors are dioxygenases that regulate the activity of
hypoxia-inducible factor (HIF), which controls renal and hepatic erythropoietin production …

Human survival is dependent upon the continuous delivery of O2 to each cell in the body in
sufficient amounts to meet metabolic requirements, primarily for ATP generation by oxidative …

In chronic kidney disease, anemia and disordered iron homeostasis are prevalent and
associated with significant adverse consequences. In 2012, Kidney Disease: Improving …

Hypoxia-inducible factor–prolyl hydroxylase domain inhibitors (HIF-PHIs) are a promising
new class of orally administered drugs currently in late-stage global clinical development for …

The Notch signaling pathway participates in pulmonary artery smooth muscle cell (PASMC)
proliferation and apoptosis. Astragaloside IV (AS‑IV) is an effective antiproliferative treatment …

Anemia is a hallmark of chronic kidney disease (CKD), worsens with disease progression,
and profoundly affects a patient's well-being. Major pathogenic factors are inadequate …

The ability to respond rapidly to changes in oxygen tension is critical for many forms of life.
Challenges to oxygen homeostasis, specifically in the contexts of evolutionary biology and …

In pulmonary hypertension (PHTN), a metabolic shift to aerobic glycolysis promotes a
hyperproliferative, apoptosis-resistant phenotype in pulmonary arterial smooth muscle cells …

Abstract Aim Hypoxia‐inducible factors (HIFs) are O2‐sensitive transcription factors that
regulate multiple biological processes which are essential for cellular adaptation to hypoxia …

Hypoxia-inducible factor (HIF) has received much attention as a potential pulmonary
hypertension (PH) treatment target because inhibition of HIF reduces the severity of …