Thirty-five years of research on p53 gave rise to more than 68,000 articles and reviews, but
did not allow the uncovering of all the mysteries that this major tumor suppressor holds. How …

The cellular stress response corresponds to the molecular changes that a cell undergoes in
response to various environmental stimuli. It induces drastic changes in the regulation of …

Senescent cells, formed in response to physiological and oncogenic stresses, facilitate
protection from tumourigenesis and aid in tissue repair. However, accumulation of such cells …

Estrogen receptor α (ERα) is a hormone receptor and key driver for over 70% of breast
cancers that has been studied for decades as a transcription factor. Unexpectedly, we …

INTRODUCTION The recruitment of the ribosome to a specific mRNA is a critical step in the
production of proteins in cells. In addition to a general recognition of the “cap” structure at …

Translational control of mRNAs is a point of convergence for many oncogenic signals
through which cancer cells tune protein expression in tumorigenesis. Cancer cells rely on …

Translation initiation of most mammalian mRNAs is mediated by a 5′ cap structure that
binds eukaryotic initiation factor 4E (eIF4E). However, inactivation of eIF4E does not impair …

It is poorly understood how a single protein, p53, can be responsive to so many stress
signals and orchestrates very diverse cell responses to maintain/restore cell/tissue functions …

The scanning model for eukaryotic mRNA translation initiation states that the small
ribosomal subunit, along with initiation factors, binds at the cap structure at the 5′ end of …

Eukaryotic translation initiation relies on the m 7 G cap present at the 5′ end of all mRNAs.
Some viral mRNAs employ alternative mechanisms of initiation based on internal ribosome …