Despite the wealth of knowledge gained about intrinsically disordered proteins (IDPs) since
their discovery, there are several aspects that remain unexplored and, hence, poorly …

Cells of the early mammalian embryo, including pluripotent embryonic stem (ES) cells and
primordial germ cells (PGCs), are epigenetically dynamic and heterogeneous. During early …

Coordinated transcription factor networks have emerged as the master regulatory
mechanisms of stem cell pluripotency and differentiation. Many stem cell-specific …

Stem cell differentiation and the maintenance of self-renewal are intrinsically complex
processes requiring the coordinated dynamic expression of hundreds of genes and proteins …

The stunning possibility of “reprogramming” differentiated somatic cells to express a
pluripotent stem cell phenotype (iPS, induced pluripotent stem cell) and the “ground state” …

Cellular reprogramming has been recently intensively studied experimentally. We
developed a global potential landscape and kinetic path framework to explore a human …

Heterogeneous expression of the transcription factor NANOG has been linked to the
existence of various functional states in pluripotent stem cells. This heterogeneity seems to …

A number of key regulators of mouse embryonic stem (ES) cell identity, including the
transcription factor Nanog, show strong expression fluctuations at the single-cell level. The …

A 30-node signed and directed network responsible for self-renewal and pluripotency of
mouse embryonic stem cells (mESCs) was extracted from several ChIP-Seq and knockdown …

High content studies that profile mouse and human embryonic stem cells (m/hESCs) using
various genome-wide technologies such as transcriptomics and proteomics are constantly …