Several recent studies in a number of model systems including zebrafish, Arabidopsis, and
mouse have revealed phenotypic differences between knockouts (ie, mutants) and …

Metallothioneins (MTs) are small cysteine-rich proteins that play important roles in metal
homeostasis and protection against heavy metal toxicity, DNA damage, and oxidative stress …

Genetic robustness, or the ability of an organism to maintain fitness in the presence of
harmful mutations, can be achieved via protein feedback loops. Previous work has …

The genetic compensation response (GCR) has recently been proposed as a possible
explanation for the phenotypic discrepancies between gene-knockout and gene …

Hundreds of human genes are associated with neurological diseases, but translation into
tractable biological mechanisms is lagging. Larval zebrafish are an attractive model to …

Metallothioneins (MTs) are small cysteine-rich intracellular proteins with four major isoforms
identified in mammals, designated MT-1 through MT-4. The best known biological functions …

Background: Per-and polyfluoroalkyl Substances (PFAS) are synthetic chemicals widely
detected in humans and the environment. Exposure to perfluorooctanesulfonic acid (PFOS) …

Diabetes-induced oxidative stress is one of the major contributors to dysfunction of
endothelial progenitor cells (EPCs) and impaired endothelial regeneration. Thus, we tested …

Abstract MicroRNA-491-5p (miR-491-5p) plays an important role in regulating cell
proliferation and migration; however, the effect of miR-491-5p on neovascularization after …

The gene dosage compensation hypothesis presents a mechanism through which the
expression of certain genes is modulated to compensate for differences in the dose of genes …