CD90 is a membrane GPI-anchored protein with one Ig V-type superfamily domain that was
initially described in mouse T cells. Besides the specific expression pattern and functions of …

Characterised by high intra‐and inter‐tumor heterogeneity, metastatic renal cell carcinoma
(RCC) is resistant to chemo‐and radiotherapy. Therefore, the development of new …

Wnt signaling pathways play important roles in tumorigenesis and are initiated by binding of
Wnt to various receptors including frizzleds (FZDs). FZDs are one of several families of …

Micro RNAs (miRNAs) play an important role during renal development and show a tissue-
specific enrichment in the kidney. Nephroblastomas, embryonal renal neoplasms of …

The Wnt signaling is of paramount pathophysiological importance. Despite showing
promising anticancer activities in pre-clinical studies, current Wnt pathway inhibitors face …

In the human fetal kidney (HFK) self-renewing stem cells residing in the metanephric
mesenchyme (MM)/blastema are induced to form all cell types of the nephron till 34th week …

End-stage renal disease (ESRD) is defined as the inability of the kidneys to remove waste
products and excess fluid from the blood. ESRD progresses from earlier stages of chronic …

There are considerable differences in tumour biology between adult and paediatric cancers.
The existence of cancer initiating cells/cancer stem cells (CIC/CSC) in paediatric solid …

Background The aim of this study was to investigate the clinical significances and prognostic
value of CD133 and CD44 (markers of cancer stem‐like cells, CSCs), and vasculogenic …

Abstract Wilms' tumor (WT), the most frequent renal solid tumor in children, has been linked
to aberrant Wnt signaling. Herein, we demonstrate that different WTs can be grouped …