Waardenburg syndrome (WS) is characterized by the association of pigmentation
abnormalities, including depigmented patches of the skin and hair, vivid blue eyes or …

The neural crest is a multipotent, migratory cell population that is unique to vertebrate
embryos and gives rise to many derivatives, ranging from the peripheral nervous system to …

INTRODUCTION The “cancerized field” concept posits that cells in a given tissue sharing an
oncogenic mutation are cancer-prone, yet only discreet clones within the field initiate tumors …

The enteric nervous system is the part of the autonomic nervous system that directly controls
the gastrointestinal tract. Derived from a multipotent, migratory cell population called the …

The enteric nervous system (ENS) has been explored by developmental neurobiologists
and medical researchers for decades. Whereas developmental biologists have been …

Despite a well-characterized lack of specificity, pathologists routinely employ S100 in the
diagnosis of neural crest-derived tumors. Recent studies have shown that Sox10 is a …

Maintain stemness, commit to a specific lineage, differentiate, proliferate, or die. These are
essential decisions that every cell is constantly challenged to make in multi-cellular …

SOX10 belongs to a family of 20 SRY (sex-determining region Y)-related high mobility group
box-containing (SOX) proteins, most of which contribute to cell type specification and …

Since its debut in the biomedical research fields in 1981, zebrafish have been used as a
vertebrate model organism in more than 40,000 biomedical research studies. Especially …

S100 protein is a sensitive marker for melanomas and peripheral nerve sheath tumors. It is,
however, expressed by other mesenchymal and epithelial tumors. Despite its low specificity …