Cardiotoxicity is a severe side effect of drugs that induce structural or electrophysiological
changes in heart muscle cells. As a result, the heart undergoes failure and potentially lethal …

Hyperpolarization-activated, cyclic nucleotide–gated (HCN) channels are important
members of the voltage-gated pore loop channels family. They show unique features: they …

Key points Induced pluripotent stem cell‐derived cardiomyocytes (iPSC‐CMs) capture
patient‐specific genotype–phenotype relationships, as well as cell‐to‐cell variability of …

Prevailing commercialized cardiac platforms for in vitro drug development utilize planar
microelectrode arrays to map action potentials, or impedance sensing to record contraction …

The clear importance of human induced pluripotent stem cell derived cardiomyocytes
(hiPSC-CMs) as an in-vitro model highlights the relevance of studying these cells and their …

The growing importance of human induced pluripotent stem cell-derived cardiomyoyctes
(hiPSC-CMs), as patient-specific and disease-specific models for studying cellular cardiac …

Background and Purpose Two new technologies are likely to revolutionize cardiac safety
and drug development: in vitro experiments on human‐induced pluripotent stem cell …

Human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes hold great potentials
to predict pro-arrhythmic risks in preclinical cardiac safety screening, although the hiPSC …

Human induced pluripotent stem cell derived cardiomyocytes (iPSC-CMs) have applications
in disease modeling, cell therapy, drug screening and personalized medicine …

Despite major efforts by clinicians and researchers, cardiac arrhythmia remains a leading
cause of morbidity and mortality in the world. Experimental work has relied on combining …