Leprosy, a disease caused by Mycobacterium leprae, has polymorphic neurocutaneous
manifestations strongly correlated with the host immune response. Peripheral neural …

In the second article in this continuing medical education series, we review the treatment of
leprosy, its immunologic reactions, and important concepts, including disease relapse and …

Leprosy, a disease caused by the intracellular parasite Mycobacterium leprae or
Mycobacterium lepromatosis, has affected humans for more than 4,000 years and is a …

Leprosy is an infectious disease that may present different clinical forms depending on host
immune response to Mycobacterium leprae. Several studies have clarified the role of …

Background Depending on the epidemiological setting, a variable proportion of leprosy
patients will suffer from excessive pro-inflammatory responses, termed type-1 reactions …

The pathways that trigger exacerbated immune reactions in leprosy could be determined by
genetic variations. Here, in a prospective approach, both genetic and non-genetic variables …

Leprosy is a chronic infectious disease that may present different clinical forms according to
the immune response of the host. Levels of IFN-γ are significantly raised in paucibacillary …

Mycobacterium leprae (ML) infection causes nerve damage that often leads to permanent
loss of cutaneous sensitivity and limb deformities, but understanding of the pathogenesis of …

Background Diagnosis of paradoxical tuberculosis-associated immune reconstitution
inflammatory syndrome (TB-IRIS) is challenging and new tools are needed for early …

Transcriptome profiles derived from the site of human disease have led to the identification
of genes that contribute to pathogenesis, yet the complex mixture of cell types in these …