7-N-Substituted-3-oxadiazole Quinolones with Potent Antimalarial Activity Target the Cytochrome bc1 Complex
W Nguyen, MG Dans, I Currie, JK Awalt… - ACS Infectious …, 2023 - ACS Publications
The development of new antimalarials is required because of the threat of resistance to
current antimalarial therapies. To discover new antimalarial chemotypes, we screened the …
current antimalarial therapies. To discover new antimalarial chemotypes, we screened the …
A patatin-like phospholipase is important for mitochondrial function in malaria parasites
E Pietsch, A Ramaprasad, S Bielfeld, Y Wohlfarter… - Mbio, 2023 - Am Soc Microbiol
Plasmodium parasites rely on a functional electron transport chain (ETC) within their
mitochondrion for proliferation, and compounds targeting mitochondrial functions are …
mitochondrion for proliferation, and compounds targeting mitochondrial functions are …
An essential role for an Fe-S cluster protein in the cytochrome c oxidase complex of Toxoplasma parasites
RA Leonard, Y Tian, F Tan, GG van Dooren… - PLoS …, 2023 - journals.plos.org
The mitochondrial electron transport chain (ETC) of apicomplexan parasites differs
considerably from the ETC of the animals that these parasites infect, and is the target of …
considerably from the ETC of the animals that these parasites infect, and is the target of …
[HTML][HTML] Plasmodium falciparum Mitochondrial Complex III, the Target of Atovaquone, Is Essential for Progression to the Transmissible Sexual Stages
PK Sheokand, S Pradhan, AE Maclean… - International Journal of …, 2024 - mdpi.com
The Plasmodium falciparum mitochondrial electron transport chain (mETC) is responsible
for essential metabolic pathways such as de novo pyrimidine synthesis and ATP synthesis …
for essential metabolic pathways such as de novo pyrimidine synthesis and ATP synthesis …
Harnessing cholesterol uptake of malaria parasites for therapeutic applications
M Fraser, B Curtis, P Phillips, PA Yates… - EMBO Molecular …, 2024 - embopress.org
Parasites, such as the malaria parasite P. falciparum, are critically dependent on host
nutrients. Interference with nutrient uptake can lead to parasite death and, therefore, serve …
nutrients. Interference with nutrient uptake can lead to parasite death and, therefore, serve …
[HTML][HTML] Exploration and characterization of the antimalarial activity of cyclopropyl carboxamides that target the mitochondrial protein, cytochrome b
JK Awalt, W Su, W Nguyen, K Loi, KE Jarman… - European journal of …, 2024 - Elsevier
Drug resistance against antimalarials is rendering them increasingly ineffective and so there
is a need for the development of new antimalarials. To discover new antimalarial …
is a need for the development of new antimalarials. To discover new antimalarial …
An adaptable, fit-for-purpose screening approach with high-throughput capability to determine speed of action and stage specificity of anti-malarial compounds
ABSTRACT A revamped in vitro compound identification and activity profiling approach is
required to meet the large unmet need for new anti-malarial drugs to combat parasite drug …
required to meet the large unmet need for new anti-malarial drugs to combat parasite drug …
A myzozoan-specific protein is an essential membrane-anchoring component of the succinate dehydrogenase complex in Toxoplasma parasites
SM Zwahlen, JA Hayward, CS Maguire… - Open …, 2024 - royalsocietypublishing.org
Succinate dehydrogenase (SDH) is a protein complex that functions in the tricarboxylic acid
cycle and the electron transport chain of mitochondria. In most eukaryotes, SDH is highly …
cycle and the electron transport chain of mitochondria. In most eukaryotes, SDH is highly …
Antimalarial mechanism of action of the natural product 9-methoxystrobilurin G
PJ Shaw, P Prommana, C Thongpanchang… - Molecular …, 2024 - pubs.rsc.org
The natural product 9-methoxystrobilurin G (9MG) from Favolaschia spp basidiomycetes is a
potent and selective antimalarial. The mechanism of action of 9MG is unknown. We induced …
potent and selective antimalarial. The mechanism of action of 9MG is unknown. We induced …
Screening the MMV Pathogen Box reveals the mitochondrial bc1-complex as a drug target in mature Toxoplasma gondii bradyzoites
D Maus, E Putrianti, T Hoffmann, M Laue, F Seeber… - bioRxiv, 2023 - biorxiv.org
The apicomplexan parasite Toxoplasma gondii infects 25-30% of the global human
population and can cause life-threatening diseases in immunocompromised patients. The …
population and can cause life-threatening diseases in immunocompromised patients. The …