Natural product-derived ferroptosis mediators

YL Chen, LA Xiong, LF Ma, L Fang, ZJ Zhan - Phytochemistry, 2024 - Elsevier
It has been 11 years since ferroptosis, a new mode of programmed cell death, was first
proposed. Natural products are an important source of drug discovery. In the past five years …

Ferroptosis inhibitors: past, present and future

L Zhang, YL Luo, Y Xiang, XY Bai, RR Qiang… - Frontiers in …, 2024 - frontiersin.org
Ferroptosis is a non-apoptotic mode of programmed cell death characterized by iron
dependence and lipid peroxidation. Since the ferroptosis was proposed, researchers have …

Andrastin-type meroterpenoids, α-pyrone polyketides, and sesquicarane derivatives from Penicillium sp., a fungus isolated from Pinus koraiensis seed

S Han, H Ma, Y Wu, C Wang, Y Li, Q Li, Z Cheng - Phytochemistry, 2024 - Elsevier
The genus Penicillium has provided us with the household antibiotic penicillin and the well-
known lipid-lowering agent mevastatin. The strain Penicillium sp. SZ-1 was found to grow …

Rapid Discovery of Substances with Anticancer Potential from Marine Fungi Based on a One Strain–Many Compounds Strategy and UPLC-QTOF-MS

YT Wu, XN Zhao, PX Zhang, CF Wang, J Li, XY Wei… - Marine Drugs, 2023 - mdpi.com
The secondary metabolites of marine fungi with rich chemical diversity and biological activity
are an important and exciting target for natural product research. This study aimed to …

Identification of a marine‐derived sesquiterpenoid, Compound‐8, that inhibits tumour necrosis factor‐induced cell death by blocking complex II assembly

Y He, T Yang, J Li, K Li, C Zhuang… - British Journal of …, 2024 - Wiley Online Library
Background and Purpose Tumour necrosis factor (TNF) is a pleiotropic inflammatory
cytokine that not only directly induces inflammatory gene expression but also triggers …

Ergone Derivatives from the Deep-Sea-Derived Fungus Aspergillus terreus YPGA10 and 25,28-Dihydroxyergone-Induced Apoptosis in Human Colon Cancer SW620 …

Z Zhang, Y Li, H Wang, W Xu, C Wang… - Journal of Natural …, 2024 - ACS Publications
Ten new ergone derivatives (1–10) and five known analogues (11–15) were isolated from
the deep-sea-derived fungus Aspergillus terreus YPGA10. The structures including the …

Polyketides and alkaloids from the fungus Aspergillus Fumigatus YB4-17 and ent-Fumiquinazoline J induce apoptosis, paraptosis in human hepatoma HepG2 cells

H Wang, L Sun, X Ma, S Jin, Y Xi, C Sai… - Frontiers in …, 2024 - frontiersin.org
Hepatocellular carcinoma (HCC) is one of the most common malignancies. The currently
available clinical drugs for HCC frequently cause serious side effects and the treatment …

Fungal aromatic-bisabolane sesquiterpenoids—possible peptidylprolyl cis/trans isomerase (Pin1) inhibitors for cancer

BE Ainousah, AA Alzain, TH Shoaib… - Mycological …, 2023 - Springer
Marine fungi have been proven as potential sources of natural metabolites with significant
bioactivities that have not been sufficiently explored. This highlights the need for intensifying …

Retrobisabolane A, a Novel Bisabolane‐Derived Sesquiterpenoid Isolated from Deep‐Sea‐Derived Fungus Retroconis fusiformis MCCC 3A00792

X Liu, Y Lv, J He, B Hong, Z Shao, M Yu… - Chemistry & …, 2024 - Wiley Online Library
One novel bisabolane‐derived sesquiterpenoid retrobisabolane A (1), featuring a methyl
group location at the C‐4 position instead of C‐3 in the bisabolanes, and a known ester …

[PDF][PDF] Butenolide Derivatives from the Fungus Aspergillus terreus and Theirα-Glucosidase Inhibitory Effects

W Shen, X Huang, K Wang - Records of Natural Products, 2023 - acgpubs.org
The strain was isolated from the sea sediment of Hangzhou Bay and was cultured on solid
fermentation using rice bran. The fermented material was extracted with ethyl acetate. The …