Spinal cord injury: molecular mechanisms and therapeutic interventions

X Hu, W Xu, Y Ren, Z Wang, X He, R Huang… - Signal transduction and …, 2023 - nature.com
Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate.
The challenges of SCI repair include its complex pathological mechanisms and the …

Traumatic spinal cord injury: an overview of pathophysiology, models and acute injury mechanisms

A Alizadeh, SM Dyck, S Karimi-Abdolrezaee - Frontiers in neurology, 2019 - frontiersin.org
Traumatic spinal cord injury (SCI) is a life changing neurological condition with substantial
socioeconomic implications for patients and their care-givers. Recent advances in medical …

Three-dimensional-cultured MSC-derived exosome-hydrogel hybrid microneedle array patch for spinal cord repair

M Han, H Yang, X Lu, Y Li, Z Liu, F Li, Z Shang… - Nano …, 2022 - ACS Publications
Exosomes derived from mesenchymal stem cells (MSCs) have been proven to exhibit great
potentials in spinal cord injury (SCI) therapy. However, conventional two-dimensional (2D) …

Progression in translational research on spinal cord injury based on microenvironment imbalance

B Fan, Z Wei, S Feng - Bone research, 2022 - nature.com
Spinal cord injury (SCI) leads to loss of motor and sensory function below the injury level
and imposes a considerable burden on patients, families, and society. Repair of the injured …

The PI3K/AKT signalling pathway in inflammation, cell death and glial scar formation after traumatic spinal cord injury: Mechanisms and therapeutic opportunities

X He, Y Li, B Deng, A Lin, G Zhang, M Ma… - Cell …, 2022 - Wiley Online Library
Abstract Objects Traumatic spinal cord injury (TSCI) causes neurological dysfunction below
the injured segment of the spinal cord, which significantly impacts the quality of life in …

Emerging role of STING signalling in CNS injury: inflammation, autophagy, necroptosis, ferroptosis and pyroptosis

X Hu, H Zhang, Q Zhang, X Yao, W Ni… - Journal of …, 2022 - Springer
Stimulator of interferons genes (STING), which is crucial for the secretion of type I interferons
and proinflammatory cytokines in response to cytosolic nucleic acids, plays a key role in the …

Treatment of spinal cord injury with mesenchymal stem cells

LL Liau, QH Looi, WC Chia, T Subramaniam, MH Ng… - Cell & bioscience, 2020 - Springer
Background Spinal cord injury (SCI) is the damage to the spinal cord that can lead to
temporary or permanent loss of function due to injury to the nerve. The SCI patients are often …

A DAMP-scavenging, IL-10-releasing hydrogel promotes neural regeneration and motor function recovery after spinal cord injury

H Shen, B Xu, C Yang, W Xue, Z You, X Wu, D Ma… - Biomaterials, 2022 - Elsevier
Spinal cord injury (SCI) creates an inflammatory microenvironment characterized by
damage-associated molecular patterns (DAMPs) and immune cell activation that exacerbate …

The translational landscape in spinal cord injury: focus on neuroplasticity and regeneration

TH Hutson, S Di Giovanni - Nature Reviews Neurology, 2019 - nature.com
Over the past decade, we have witnessed a flourishing of novel strategies to enhance
neuroplasticity and promote axon regeneration following spinal cord injury, and results from …

Acute and non-resolving inflammation associate with oxidative injury after human spinal cord injury

T Zrzavy, C Schwaiger, I Wimmer, T Berger, J Bauer… - Brain, 2021 - academic.oup.com
Traumatic spinal cord injury is a devastating insult followed by progressive cord atrophy and
neurodegeneration. Dysregulated or non-resolving inflammatory processes can disturb …