Down syndrome (DS) is one of the leading causes of intellectual disability, and patients with
DS face various health issues, including learning and memory deficits, congenital heart …

Down syndrome is caused by trisomy of chromosome 21. To date, a multiplicity of mouse
models with Down-syndrome-related features has been developed to understand this …

Background Early cognitive intervention is the only routine therapeutic approach used for
amelioration of intellectual deficits in individuals with Down's syndrome, but its effects are …

Intellectual disability (ID) is the unavoidable hallmark of Down syndrome (DS), with a heavy
impact on public health. Accumulating evidence shows that DS is characterized by …

Down syndrome (DS) is a genetic disease that occurs due to an aneuploidy of human
chromosome 21. Trisomy of chromosome 21 is a primary genetic cause of developmental …

Stroke is a common cerebrovascular disease that can interrupt local blood flow in the brain,
causing neuronal damage or even death, resulting in varying degrees of neurological …

Down syndrome (DS) caused by a trisomy of chromosome 21 (HSA21), is the most common
genetic developmental disorder, with an incidence of 1 in 800 live births. Its phenotypic …

Harmine is the β-carboline alkaloid with the highest concentration in the psychotropic plant
decoction Ayahuasca. In rodents, classical antidepressants reverse the symptoms of …

Growing evidence supports the implication of DYRK1A in the development of cognitive
deficits seen in Down syndrome (DS) and Alzheimer's disease (AD). We here demonstrate …

The most common genetic cause of intellectual disability is Down syndrome (DS), trisomy
21. It commonly results from three copies of human chromosome 21 (HC21). There are no …