Macrolide antibiotics inhibit protein synthesis by targeting the bacterial ribosome. They bind
at the nascent peptide exit tunnel and partially occlude it. Thus, macrolides have been …

The chemical synthesis of modified oligoribonucleotides represents a powerful approach to
study the structure, stability, and biological activity of RNAs. Selected RNA modifications …

Intracellular levels of reactive oxygen species (ROS) increase as a consequence of
oxidative stress and represent a major source of damage to biomolecules. Due to its high …

During protein synthesis, the growing polypeptide threads through the ribosomal exit tunnel
and modulates ribosomal activity by itself or by sensing various small molecules, such as …

It is a widespread concern that the extensive use of antibiotics has caused not only harm to
the human body but also heavy environmental pollution. Because of its high efficiency and …

The antibiotic linezolid, the first clinically approved member of the oxazolidinone class,
inhibits translation of bacterial ribosomes by binding to the peptidyl transferase center …

Directed evolution of the ribosome for expanded substrate incorporation and novel functions
is challenging because the requirement of cell viability limits the mutations that can be …

Methods to directly inhibit gene expression using small molecules hold promise for the
development of new therapeutics targeting proteins that have evaded previous attempts at …

The clinical use of the antibiotic erythromycin (ery) is hampered owing to the spread of
resistance genes that are mostly mutating rRNA around the ery binding site at the entrance …

Bacterial ribosome rescue pathways that remove ribosomes stalled on mRNAs during
translation have been proposed as novel antibiotic targets because they are essential in …