Eugenol: A novel therapeutic agent for the inhibition of Candida species infection

M Didehdar, Z Chegini, A Shariati - Frontiers in Pharmacology, 2022 - frontiersin.org
The high occurrence and mortality rates related to candidiasis emphasize the urgent need to
introduce new therapeutic approaches to treat this infection. Eugenol, the main phenolic …

Update on fungal lipid biosynthesis inhibitors as antifungal agents

M Vishwakarma, T Haider, V Soni - Microbiological Research, 2023 - Elsevier
Fungal diseases today represent a world-wide problem. Poor hygiene and decreased
immunity are the main reasons behind the manifestation of this disease. After COVID-19, an …

Potential Inhibitors of CYP51 Enzyme in Dermatophytes by Red Sea Soft Coral Nephthea sp.: In Silico and Molecular Networking Studies

NH Hassan, SS El-Hawary, M Emam, MA Rabeh… - ACS …, 2022 - ACS Publications
In this study, the n-hexane fraction of soft coral Nephthea sp. gathered from the Red Sea
was evaluated for its antidermatophyte activity. The antidermatophyte activity was performed …

Antifungal Annona muricata L.(soursop) extract targets the cell envelope of multi-drug resistant Candida albicans

LM Campos, ASO Lemos, IOM Diniz… - Journal of …, 2023 - Elsevier
Etnopharmacological relevance Annona muricata L.(soursop) is traditionally used in the
treatment of inflammatory diseases, cancer, and infections caused by fungi. The therapeutic …

Cellular apoptosis and necrosis as therapeutic targets for novel Eugenol Tosylate Congeners against Candida albicans

SA Lone, MY Wani, P Fru, A Ahmad - Scientific Reports, 2020 - nature.com
Despite the rise of new Candida species, Candida albicans tops the list with high morbidity
and mortality rates. To tackle this problem there is a need to explore new antifungals that …

Antifungal Activities of cis-trans Citral Isomers against Trichophyton rubrum with ERG6 as a Potential Target

Y Zheng, Y Shang, M Li, Y Li, W Ouyang - Molecules, 2021 - mdpi.com
Trichophyton rubrum causes ringworm worldwide. Citral (CIT), extracted from Pectis plants,
is a monoterpene and naturally composed of geometric isomers neral (cis-citral) and …

Exploring binding mechanism of naringenin to human transferrin using combined spectroscopic and computational methods: Towards therapeutic targeting of …

S Khan, FA Alhumaydhi, MS Khan, SE Sharaf… - Journal of Molecular …, 2022 - Elsevier
Excessive iron deposition is linked to the pathology of neurodegenerative, signifying the
importance of iron homeostasis. Together with ferritin, human transferrin (hTf) play …

Unravelling the antifungal mode of action of curcumin by potential inhibition of CYP51B: A computational study validated in vitro on mucormycosis agent, Rhizopus …

J Prajapati, P Rao, L Poojara, D Goswami… - Archives of Biochemistry …, 2021 - Elsevier
Like human, fungi too are known to share lot of structural similarities amongst their CYPs
(Cytochrome P450 super family of enzymes) which allows antifungal 'azole'compounds to …

Anti‐Candida, docking studies, and in vitro metabolism‐mediated cytotoxicity evaluation of Eugenol derivatives

JAP Dutra, SC Maximino… - Chemical Biology & …, 2023 - Wiley Online Library
The high morbidity and mortality rates of Candida infections, especially among
immunocompromised patients, are related to the increased resistance rate of these species …

Recent advances in the application of essential oils as potential therapeutic candidates for candida-related infections

HNH Tran, S Udoh, G Russell, OR Okeyoyin… - Applied …, 2022 - mdpi.com
Candidiasis (oral, vulvovaginal, or systemic bloodstream infections) are important human
fungal infections associated with a high global prevalence in otherwise healthy adults but …