Pigment epithelial cells (PECs) of the retina (RPE), ciliary body, and iris (IPE) are capable of
altering their phenotype. The main pathway of phenotypic switching of eye PECs in …

The main degenerative diseases of the retina include macular degeneration, proliferative
vitreoretinopathy, retinitis pigmentosa, and glaucoma. Novel approaches for treating retinal …

The cornea fends off chemicals, dirt, and infectious particles and provides most of the eye's
focusing power. Corneal transparency is of paramount importance to normal vision, yet how …

It can be challenging to maintain tissue integrity using established histology protocols. Here,
we describe a protocol composed of Hartman's fixation, window technique, microwave …

Single‐cell RNA sequencing (scRNA‐seq) technologies enable the profiling and analysis of
the transcriptomes of single cells and hold promise for clarifying gene mechanisms at single …

The ciliary body, located at the junction of the choroid and iris, is crucial in the development
of the embryonic eye. Notch2 signalling, Wnt signalling, transforming growth factor β (TGF-β) …

Investigating the function of delicate mammalian eyes often requires chemical fixation,
histological sectioning, immunohistochemistry (IHC) and in situ hybridization (ISH). One of …

A collective cell motility event that occurs during Drosophila eye development, ommatidial
rotation (OR), serves as a paradigm for signaling-pathway-regulated directed movement of …

Zusammenfassung Kongenitale Augenfehlbildungen wie das Mikrophthalmie-Anophthalmie-
Kolobom-Spektrum (MAC), Vorderabschnittsdysgenesien (ASD), das kongenitale Glaukom …

Purpose: NOTCH signaling has neuroprotective functions and altered NOTCH signaling is
associated with neurodegenerative diseases with protein aggregation such as Alzheimer …