Improved global protein homolog detection with major gains in function identification
There are several hundred million protein sequences, but the relationships among them are
not fully available from existing homolog detection methods. There is an essential need for …
not fully available from existing homolog detection methods. There is an essential need for …
[HTML][HTML] The Historical Evolution and Significance of Multiple Sequence Alignment in Molecular Structure and Function Prediction
Multiple sequence alignment (MSA) has evolved into a fundamental tool in the biological
sciences, playing a pivotal role in predicting molecular structures and functions. With broad …
sciences, playing a pivotal role in predicting molecular structures and functions. With broad …
Fast and accurate Ab Initio Protein structure prediction using deep learning potentials
Despite the immense progress recently witnessed in protein structure prediction, the
modeling accuracy for proteins that lack sequence and/or structure homologs remains to be …
modeling accuracy for proteins that lack sequence and/or structure homologs remains to be …
GradPose: a very fast and memory-efficient gradient descent-based tool for superimposing millions of protein structures from computational simulations
DT Rademaker, KJ van Geemen, LC Xue - Bioinformatics, 2023 - academic.oup.com
Computational simulations like molecular dynamics and docking are providing crucial
insights into the dynamics and interaction conformations of proteins, complementing …
insights into the dynamics and interaction conformations of proteins, complementing …
[HTML][HTML] Accurate prediction of immunoglobulin proteins using machine learning model
Introduction In recent years, researchers have become increasingly interested in
immunoglobulins. The antibodies, also known as immunoglobulins, are serum proteins that …
immunoglobulins. The antibodies, also known as immunoglobulins, are serum proteins that …
The PARP inhibitor rucaparib blocks SARS‐CoV‐2 virus binding to cells and the immune reaction in models of COVID‐19
Abstract Background and Purpose To date, there are limited options for severe Coronavirus
disease 2019 (COVID‐19), caused by SARS‐CoV‐2 virus. As ADP‐ribosylation events are …
disease 2019 (COVID‐19), caused by SARS‐CoV‐2 virus. As ADP‐ribosylation events are …
From structure prediction to function: defining the domain on the African swine fever virus CD2v protein required for binding to erythrocytes
AL Reis, A Rathakrishnan, V Petrovan, M Islam… - mBio, 2024 - journals.asm.org
African swine fever virus (ASFV) is a high-consequence pathogen posing a substantial
threat to global food security. This large DNA virus encodes more than 150 open reading …
threat to global food security. This large DNA virus encodes more than 150 open reading …
DeepImmuno-PSSM: Identification of Immunoglobulin based on Deep learning and PSSM-Profiles
Immunoglobulin has a close connection to a number of disorders and is important in both
biological and medicinal contexts. Therefore, it is crucial for illness research to employ …
biological and medicinal contexts. Therefore, it is crucial for illness research to employ …
Developing similarity matrices for antibody-protein binding interactions
S Islam, RJ Pantazes - Plos one, 2023 - journals.plos.org
The inventions of AlphaFold and RoseTTAFold are revolutionizing computational protein
science due to their abilities to reliably predict protein structures. Their unprecedented …
science due to their abilities to reliably predict protein structures. Their unprecedented …
Identification of the Genome Segments of Bluetongue Virus Type 26/Type 1 Reassortants Influencing Horizontal Transmission in a Mouse Model
Bluetongue virus serotypes 1 to 24 are transmitted primarily by infected Culicoides midges,
in which they also replicate. However,“atypical” BTV serotypes (BTV-25,-26,-27 and-28) …
in which they also replicate. However,“atypical” BTV serotypes (BTV-25,-26,-27 and-28) …