Tunnels for protein export from the endoplasmic reticulum
I Raote, V Malhotra - Annual review of biochemistry, 2021 - annualreviews.org
The functions of coat protein complex II (COPII) coats in cargo packaging and the creation of
vesicles at the endoplasmic reticulum are conserved in eukaryotic protein secretion …
vesicles at the endoplasmic reticulum are conserved in eukaryotic protein secretion …
Sorting and export of proteins at the endoplasmic reticulum
Secretory proteins are transported from the endoplasmic reticulum (ER) to the Golgi complex
in carriers that are formed by the concerted activities of cytoplasmic proteins in the coat …
in carriers that are formed by the concerted activities of cytoplasmic proteins in the coat …
A model for collagen secretion by intercompartmental continuities
L Bunel, L Pincet, V Malhotra… - Proceedings of the …, 2024 - National Acad Sciences
Newly synthesized secretory proteins are exported from the endoplasmic reticulum (ER) at
specialized subcompartments called exit sites (ERES). Cargoes like procollagen are too …
specialized subcompartments called exit sites (ERES). Cargoes like procollagen are too …
The small GTPase Sar1, control centre of COPII trafficking
SE Van der Verren, G Zanetti - FEBS letters, 2023 - Wiley Online Library
Sar1 is a small GTPase of the ARF family. Upon exchange of GDP for GTP, Sar1 associates
with the endoplasmic reticulum (ER) membrane and recruits COPII components …
with the endoplasmic reticulum (ER) membrane and recruits COPII components …
A tango for coats and membranes: New insights into ER-to-Golgi traffic
M Aridor - Cell reports, 2022 - cell.com
The realization that the meticulous organization of cellular organelles is not required for the
reconstitution of select intracellular traffic steps has revolutionized cell biology. It transformed …
reconstitution of select intracellular traffic steps has revolutionized cell biology. It transformed …
[HTML][HTML] TANGO1 marshals the early secretory pathway for cargo export
TANGO1 protein facilitates the endoplasmic reticulum (ER) export of large cargoes that
cannot be accommodated in 60 nm transport vesicles. It assembles into a ring in the plane of …
cannot be accommodated in 60 nm transport vesicles. It assembles into a ring in the plane of …
Quality control of procollagen in cells
S Ito, K Nagata - Annual Review of Biochemistry, 2021 - annualreviews.org
Collagen is the most abundant protein in mammals. A unique feature of collagen is its triple-
helical structure formed by the Gly-Xaa-Yaa repeats. Three single chains of procollagen …
helical structure formed by the Gly-Xaa-Yaa repeats. Three single chains of procollagen …
The conserved transmembrane protein TMEM-39 coordinates with COPII to promote collagen secretion and regulate ER stress response
Dysregulation of collagen production and secretion contributes to aging and tissue fibrosis
of major organs. How procollagen proteins in the endoplasmic reticulum (ER) route as …
of major organs. How procollagen proteins in the endoplasmic reticulum (ER) route as …
Signal peptide features determining the substrate specificities of targeting and translocation components in human ER protein import
In human cells, approximately 30% of all polypeptides enter the secretory pathway at the
level of the endoplasmic reticulum (ER). This process involves cleavable amino-terminal …
level of the endoplasmic reticulum (ER). This process involves cleavable amino-terminal …
Interorganelle communication and membrane shaping in the early secretory pathway
P Lujan, J Angulo-Capel, M Chabanon… - Current Opinion in Cell …, 2021 - Elsevier
Biomolecules in the secretory pathway use membrane trafficking for reaching their final
intracellular destination or for secretion outside the cell. This highly dynamic and multipartite …
intracellular destination or for secretion outside the cell. This highly dynamic and multipartite …