Epithelial tight junctions define the paracellular permeability of the intestinal barrier.
Molecules can cross the tight junctions via two distinct size-selective and charge-selective …

A fundamental function of the intestinal epithelium is to act as a barrier that limits interactions
between luminal contents such as the intestinal microbiota, the underlying immune system …

Sepsis is characterized by a dysregulated immune response to infection leading to life-
threatening organ dysfunction. Sepsis-induced liver injury is recognized as a powerful …

Mucosal barriers separate self from non-self and are essential for life. These barriers, which
are the first line of defense against external pathogens, are formed by epithelial cells and the …

Defective epithelial barrier function is present in maladies including epidermal burn injury,
environmental lung damage, renal tubular disease, and a range of immune-mediated and …

Inflammatory bowel disease is characterized by defects in epithelial function and
dysregulated inflammatory signaling by lamina propria mononuclear cells including …

Intestinal barrier dysfunction is thought to contribute to the development of multiple organ
dysfunction syndrome in sepsis. Although there are similarities in clinical course following …

Allogeneic hematopoietic cell transplantation (HCT) is a well-established therapeutic
modality effective for a variety of hematological malignancies but, unfortunately, is …

The epithelial cell tight junction structure is the site of the transepithelial movement of solutes
and water between epithelial cells (paracellular permeability). Paracellular permeability can …

Graft-versus-host response after allogeneic hematopoietic stem cell transplantation (allo-
HCT) represents one of the most intense inflammatory responses observed in humans. Host …