Airway epithelial barrier dysfunction is frequently observed in asthma and may have
important implications. The physical barrier function of the airway epithelium is tightly …

Non-type 2 inflammation (Non-T2)-mediated asthma is difficult to define due to lack of
signature biomarkers. It exists in the absence of T2-high or eosinophilic inflammation and …

Asthma is a multifactorial disorder, and microbial dysbiosis enhances lung inflammation and
asthma-related symptoms. Probiotics have shown anti-inflammatory effects and could …

Sphingolipids are essential lipids in eukaryotic membranes. In humans, the first and rate-
limiting step of sphingolipid synthesis is catalyzed by the serine palmitoyltransferase …

Environmental exposures during early life play a critical role in life-course health, yet the
molecular phenotypes underlying environmental effects on health are poorly understood. In …

Allergic diseases and asthma are heterogenous chronic inflammatory conditions with
several distinct complex endotypes. Both environmental and genetic factors can influence …

Asthma is a prevalent pulmonary disease that affects more than 300 million people
worldwide and imposes a substantial economic burden. While medication can effectively …

Rationale: A link among sphingolipids, 17q21 genetic variants, and childhood asthma has
been suggested, but the underlying mechanisms and characteristics of such an asthma …

Respiratory infections are a leading cause of child morbidity worldwide, and asthma is the
most common chronic disorder in childhood. Both conditions associate with high …

abstract Asthma is a syndrome with extremely diverse clinical phenotypes in which the
onset, severity, and response to treatment are defined by the complex interplay of many …