[HTML][HTML] Blood-brain barrier leakage in Alzheimer's disease: From discovery to clinical relevance

G Nehra, B Bauer, AMS Hartz - Pharmacology & therapeutics, 2022 - Elsevier
Alzheimer's disease (AD) is the most common form of dementia. AD brain pathology starts
decades before the onset of clinical symptoms. One early pathological hallmark is blood …

Neprilysin inhibitors and risk of Alzheimer's disease: A future perspective

NH Ali, HM Al‐Kuraishy, AI Al‐Gareeb… - Journal of cellular …, 2024 - Wiley Online Library
Alzheimer's disease (AD) is a heterogeneous neurodegenerative disease with multifaceted
neuropathological disorders. AD is characterized by intracellular accumulation of …

A possible mechanism for the enhanced toxicity of beta-amyloid protofibrils in Alzheimer's disease

ZL Chen, PK Singh, M Calvano… - Proceedings of the …, 2023 - National Acad Sciences
The amyloid-beta peptide (Aβ) is a driver of Alzheimer's disease (AD). Aβ monomers can
aggregate and form larger soluble (oligomers/protofibrils) and insoluble (fibrils) forms. There …

Vascular Dysfunction in Alzheimer's Disease: Alterations in the Plasma Contact and Fibrinolytic Systems

A Badimon, D Torrente, EH Norris - International journal of molecular …, 2023 - mdpi.com
Alzheimer's disease (AD) is the most common neurodegenerative disease, affecting millions
of people worldwide. The classical hallmarks of AD include extracellular beta-amyloid (Aβ) …

Astrocytic calcium and cAMP in neurodegenerative diseases

M Sobolczyk, T Boczek - Frontiers in Cellular Neuroscience, 2022 - frontiersin.org
It is commonly accepted that the role of astrocytes exceeds far beyond neuronal scaffold and
energy supply. Their unique morphological and functional features have recently brough …

A modular map of Bradykinin-mediated inflammatory signaling network

DAB Rex, K Deepak, N Vaid, S Dagamajalu… - Journal of Cell …, 2022 - Springer
Bradykinin, a member of the kallikrein-kinin system (KKS), is associated with an
inflammatory response pathway with diverse vascular permeability functions, including …

Cognitive impairment in heart failure: landscape, challenges, and future directions

M Yang, D Sun, Y Wang, M Yan, J Zheng… - Frontiers in …, 2022 - frontiersin.org
Heart failure (HF) is a major global healthcare problem accounting for substantial
deterioration of prognosis. As a complex clinical syndrome, HF often coexists with multi …

Angiotensin receptor blockers and cognition: a scoping review

Z Zhou, SG Orchard, MR Nelson, MA Fravel… - Current hypertension …, 2024 - Springer
Abstract Purpose of Review To provide an overview of the association between angiotensin
II receptor blocker (ARB) use and cognitive outcomes. Recent Findings ARBs have …

Direct oral anticoagulants (DOACs) for therapeutic targeting of thrombin, a key mediator of cerebrovascular and neuronal dysfunction in Alzheimer's disease

K Grossmann - Biomedicines, 2022 - mdpi.com
Although preclinical research and observer studies on patients with atrial fibrillation
concluded that direct oral anticoagulants (DOACs) can protect against dementia like …

[HTML][HTML] A correlative relationship between heart failure and cognitive impairment: a narrative review

MS Park, EJ Kim - Journal of Korean Medical Science, 2023 - ncbi.nlm.nih.gov
Heart failure (HF) is a chronic condition affecting millions of people worldwide. While the
cardinal manifestations of HF are related to the cardiovascular system, it has become …