Doxorubicin (Dox) is a secondary metabolite of the mutated strain of Streptomyces peucetius
var. Caesius and belongs to the anthracyclines family. The anti-cancer activity of Dox is …

Simple Summary The number of children and adults with cancer that are completely cured is
still increasing thanks to effective anti-cancer therapy, but they may be confronted with the …

Anthracyclines have been important and effective treatments against a number of cancers
since their discovery. However, their use in therapy has been complicated by severe side …

The anthracycline drug doxorubicin is among the most used—and useful—
chemotherapeutics. While doxorubicin is highly effective in the treatment of various …

Anthracycline-based chemotherapy can result in the development of a cumulative and
progressively developing cardiomyopathy. Doxorubicin is one of the most highly prescribed …

Chemotherapy is a well-known and effective treatment for different cancers; unfortunately, it
has not been as efficient in the eradication of all cancer cells as been expected. The …

Cellular senescence suppresses cancer by irreversibly arresting cell proliferation.
Senescent cells acquire a proinflammatory senescence-associated secretory phenotype …

Adjuvant is an essential component in subunit vaccines. Many agonists of pathogen
recognition receptors have been developed as potent adjuvants to optimize the …

Many cancer type-specific anticancer agents have been developed and significant
advances have been made toward precision medicine in cancer treatment. However …

Transcriptionally active chromatin is marked by tri-methylation of histone H3 at lysine 4
(H3K4me3) located after first exons and around transcription start sites. This epigenetic mark …