Chemokine receptors are members of the G protein-coupled receptor superfamily. These
receptors are intimately involved in cell movement, and thus play a critical role in several …

Heterotrimeric G proteins (Gα, Gβ/Gγ subunits) constitute one of the most important
components of cell signaling cascade. G Protein Coupled Receptors (GPCRs) perceive …

Chemokine receptors are critical regulators of cell migration in the context of immune
surveillance, inflammation, and development. The G protein–coupled chemokine receptor …

Heterozygous autosomal dominant mutations in the CXCR4 gene cause WHIM syndrome, a
severe combined immunodeficiency disorder. The mutations primarily affect the C-terminal …

G-protein-coupled receptors (GPCRs) are, and will probably remain, the most tractable class
of targets for the development of small-molecule therapeutic medicines. Currently, all …

Plant growth and development are coordinalely controlled by several internal factors and
environmental signals. To sense these environmental signals, the higher plants have …

Whether G protein-coupled receptors (GPCR s) exist in plants is a fundamental biological
question. Interest in deorphanizing new GPCR s arises because of their importance in …

G protein‐coupled receptors are one of the most actively studied families of proteins.
However, despite the ubiquity of protein dimerization and oligomerization as a structural and …

The calcitonin receptor (CTR) and calcitonin receptor‐like receptor (CLR) are two of the 15
human family B (or Secretin‐like) GPCRs. CTR and CLR are of considerable biological …

Any aspect of cell activity is regulated by extracellular signals that are recognized, decoded,
and transduced inside the cell via different classes of plasma membrane receptors. 1À3 G …