Human organoid models to study SARS-CoV-2 infection
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is one of the deadliest pandemics in history. SARS …
syndrome coronavirus 2 (SARS-CoV-2) is one of the deadliest pandemics in history. SARS …
Post-COVID-19 syndrome: involvement and interactions between respiratory, cardiovascular and nervous systems
Though the acute effects of SARS-CoV-2 infection have been extensively reported, the long-
term effects are less well described. Specifically, while clinicians endure to battle COVID-19 …
term effects are less well described. Specifically, while clinicians endure to battle COVID-19 …
Alterations in microbiota of patients with COVID-19: potential mechanisms and therapeutic interventions
The global coronavirus disease 2019 (COVID-19) pandemic is currently ongoing. It is
caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A high …
caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A high …
Human pluripotent-stem-cell-derived organoids for drug discovery and evaluation
Human pluripotent stem cells (hPSCs) and three-dimensional organoids have ushered in a
new era for disease modeling and drug discovery. Over the past decade, significant …
new era for disease modeling and drug discovery. Over the past decade, significant …
[HTML][HTML] Vascular cells improve functionality of human cardiac organoids
Crosstalk between cardiac cells is critical for heart performance. Here we show that vascular
cells within human cardiac organoids (hCOs) enhance their maturation, force of contraction …
cells within human cardiac organoids (hCOs) enhance their maturation, force of contraction …
Long COVID and hypertension-related disorders: a report from the Japanese Society of Hypertension Project Team on COVID-19
C Matsumoto, S Shibata, T Kishi, S Morimoto… - Hypertension …, 2023 - nature.com
Abstracts The coronavirus disease 2019 (COVID-19) affects infected patients even after the
acute phase and impairs their health and quality of life by causing a wide variety of …
acute phase and impairs their health and quality of life by causing a wide variety of …
SARS-CoV-2 spike protein induces paracrine senescence and leukocyte adhesion in endothelial cells
Increased mortality in COVID-19 cases is often associated with microvascular complications.
We have recently shown that severe acute respiratory syndrome coronavirus 2 (SARS-CoV …
We have recently shown that severe acute respiratory syndrome coronavirus 2 (SARS-CoV …
BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2
AJ Samelson, QD Tran, R Robinot, L Carrau… - Nature cell …, 2022 - nature.com
SARS-CoV-2 infection of human cells is initiated by the binding of the viral Spike protein to
its cell-surface receptor ACE2. We conducted a targeted CRISPRi screen to uncover …
its cell-surface receptor ACE2. We conducted a targeted CRISPRi screen to uncover …
Enhanced metanephric specification to functional proximal tubule enables toxicity screening and infectious disease modelling in kidney organoids
JM Vanslambrouck, SB Wilson, KS Tan… - Nature …, 2022 - nature.com
While pluripotent stem cell-derived kidney organoids are now being used to model renal
disease, the proximal nephron remains immature with limited evidence for key functional …
disease, the proximal nephron remains immature with limited evidence for key functional …
Human engineered heart tissue models for disease modeling and drug discovery
The emergence of human induced pluripotent stem cells (hiPSCs) and efficient
differentiation of hiPSC-derived cardiomyocytes (hiPSC-CMs) induced from diseased …
differentiation of hiPSC-derived cardiomyocytes (hiPSC-CMs) induced from diseased …