This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

The endothelium can evoke relaxations of the underlying vascular smooth muscle, by
releasing vasodilator substances. The best‐characterized endothelium‐derived relaxing …

The measurement of vascular function in isolated vessels has revealed important insights
into the structural, functional, and biomechanical features of the normal and diseased …

The ion channels Piezo1 and TRPV4 have both, independently, been implicated in high
venous pressure–and fluid shear stress–induced vascular hyperpermeability in endothelial …

Transient receptor potential vanilloid type 4 (TRPV4) is a calcium-permeable nonselective
cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol …

Mechanotransduction plays a crucial role in vascular biology. One example of this is the
local regulation of vascular resistance via flow-mediated dilation (FMD). Impairment of this …

Capillaries are equipped to sense neurovascular coupling agents released onto the outer
wall of a capillary, translating these external signals into electrical/Ca2+ changes that play a …

The mammalian genome encodes 28 distinct members of the transient receptor potential
(TRP) superfamily of cation channels, which exhibit varying degrees of selectivity for …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Major features of the transcellular signaling mechanism responsible for endothelium-
dependent regulation of vascular smooth muscle tone are unresolved. We identified local …