B cell and T cell receptor repertoires compose the adaptive immune receptor repertoire
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …

Abstract Machine learning is increasingly used to discover diagnostic and prognostic
biomarkers from high-dimensional molecular data. However, a variety of factors related to …

Cost-efficient library generation by early barcoding has been central in propelling single-cell
RNA sequencing. Here, we optimize and validate prime-seq, an early barcoding bulk RNA …

In adaptive immune receptor repertoire analysis, determining the germline variable (V) allele
associated with each T-and B-cell receptor sequence is a crucial step. This process is highly …

The immune system is a dynamic feature of each individual and a footprint of our unique
internal and external exposures. Indeed, the type and level of exposure to physical and …

The process of recombination between variable (V), diversity (D), and joining (J)
immunoglobulin (Ig) gene segments determines an individual's naive Ig repertoire and …

Abstract Current Adaptive Immune Receptor Repertoire sequencing (AIRR-seq) using short-
read sequencing strategies resolve expressed Ab transcripts with limited resolution of the C …

The adaptive immune system holds invaluable information on past and present immune
responses in the form of B and T cell receptor sequences, but we are limited in our ability to …

Mounting experimental and clinical evidence has revealed that adaptive immune
mechanisms targeting myocardial antigens are triggered by different forms of cardiac injury …

Immunological memory protects the human body from re-infection with an earlier recognized
pathogen. This memory comprises the durable serum antibody titres provided by long-lived …