While modernization has dramatically increased lifespan, it has also witnessed the nature of
stress has changed dramatically. Chronic stress result failures of homeostasis and thus lead …

The triggering of innate immune mechanisms is emerging as a crucial component of major
neurodegenerative diseases. Microglia and other cell types in the brain can be activated in …

Parkinson's disease (PD) is associated with increased iron levels in the substantia nigra
(SNc). This study evaluated whether the iron chelator, deferiprone, is well tolerated, able to …

It has been suggested that cytokine-mediated inflammation plays a key role for the onset
and/or development of neurodegenerative diseases including Alzheimer's disease (AD) …

Inflammation is associated with many neurodegenerative diseases, including Alzheimer's
disease, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis. In this …

Although activity that induced tumor regression was observed and termed tumor necrosis
factor (TNF) as early as the 1960s, the true identity of TNF was not clear until 1984, when …

Background Emerging evidence indicates that inflammasome-induced inflammation plays a
crucial role in the pathogenesis of Parkinson's disease (PD). Several proteins including α …

J. Neurochem.(2012) 121, 4–27. Abstract Neuroglial cells define brain homeostasis and
mount defense against pathological insults. Astroglia regulate neurogenesis and …

Aluminum (Al) is a very common component of the earth's mineral composition. It is not
essential element for life and is a constituent of rather inert minerals. Therefore, it has often …

Nurr1, an orphan nuclear receptor, plays an essential role in the generation and
maintenance of dopaminergic neurons in the brain. Rare mutations in Nurr1 are associated …